Abstract p16 Ink4a is a protein involved in regulation of the cell cycle. Currently, p16 Ink4a is
considered a tumor suppressor protein because of its physiological role and downregulated …

The past two decades have witnessed an explosion in our understanding of pancreatic
cancer, and it is now clear that pancreatic cancer is a disease of inherited (germ-line) and …

Purpose: Familial pancreatic cancer kindreds contain at least two affected first-degree
relatives. Comprehensive data are needed to assist clinical risk assessment and genetic …

This review deals with germ-line genes that increase susceptibility to five major types of
cancer: breast, lung, pancreatic, prostate, and colorectal cancer. Often familial, often …

The targeted delivery of a drug should result in enhanced therapeutic efficacy with low to
minimal side effects. This is a widely accepted concept, but limited in application due to lack …

It has been suggested that~ 10% of pancreatic cancer has a familial basis 1, 2. Individuals
with a family history of pancreatic cancer have an increased risk of developing both …

Background & Aims: Relatives of patients with pancreatic cancer and persons with certain
inherited syndromes are at increased risk for developing pancreatic cancer. We …

Background Pancreatic cancer carries a dismal prognosis but there has been a vast
increase in evidence on its management in the past decade. Methods An electronic and …

A family is described showing concordance for malignant melanoma and a cutaneous
phenotype characterised by multiple large moles of variable size and colour (reddish-brown …

Although CDKN2A is well-known as a susceptibility gene for melanoma and pancreatic
cancer, germline variants have also been anecdotally associated with a broader range of …