Free radicals are chemical species (atoms, molecules, or ions) containing one or more
unpaired electrons in their external orbitals and generally display a remarkable reactivity …

Singlet oxygen (1O2) is a biologically relevant reactive oxygen species capable of efficiently
reacting with cellular constituents. The resulting oxidatively generated damage to nucleic …

Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …

In this review we provide an analysis of the biochemistry of peroxynitrite and tyrosine
nitration. Peroxynitrite is the product of the diffusion-controlled reaction between superoxide …

The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …

Peroxynitrite is the product of the diffusion-controlled reaction of nitric oxide and superoxide
radicals. Peroxynitrite, a reactive short-lived peroxide with ap K a of 6.8, is a good oxidant …

BACKGROUND: N-acetylcysteine (NAC) has been in clinical practice for several decades. It
has been used as a mucolytic agent and for the treatment of numerous disorders including …

The plasma compartment has particular features regarding the nature and concentration of
low and high molecular weight thiols and oxidized derivatives. Plasma is relatively poor in …

Red cell diseases encompass a group of inherited or acquired erythrocyte disorders that
affect the structure, function, or production of red blood cells (RBCs). These disorders can …

In this review article, emphasis is placed on the critical survey of available data concerning
modified nucleobase and 2-deoxyribose products that have been identified in cellular DNA …