Chromosome organization in bacteria: mechanistic insights into genome structure and function

RT Dame, FZM Rashid, DC Grainger - Nature Reviews Genetics, 2020 - nature.com
Bacterial chromosomes are folded to compact DNA and facilitate cellular processes.
Studying model bacteria has revealed aspects of chromosome folding that are applicable to …

Structure and function of bacterial H-NS protein

DC Grainger - Biochemical society transactions, 2016 - portlandpress.com
The histone-like nucleoid structuring (H-NS) protein is a major component of the folded
chromosome in Escherichia coli and related bacteria. Functions attributed to H-NS include …

H-NS and RNA polymerase: a love–hate relationship?

R Landick, JT Wade, DC Grainger - Current opinion in microbiology, 2015 - Elsevier
Highlights•Similarities in the DNA binding properties of H-NS and RNA polymerase.•
Interactions between H-NS and RNA polymerase throughout the transcription cycle.•H-NS …

[HTML][HTML] CD38 causes autophagic flux inhibition and cardiac dysfunction through a transcriptional inhibition pathway under hypoxia/ischemia conditions

X Zhang, L Li, Q Zhang, Q Wei, J Lin, J Jia… - Frontiers in Cell and …, 2020 - frontiersin.org
Induced autophagy is protective against myocardial hypoxia/ischemia (H/I) injury, but
evidence regarding the extent of autophagic clearance under H/I and the molecular …

Repression by H‐NS of genes required for the biosynthesis of the Vibrio cholerae biofilm matrix is modulated by the second messenger cyclic diguanylic acid

JC Ayala, H Wang, AJ Silva… - Molecular …, 2015 - Wiley Online Library
Expression of V ibrio cholerae genes required for the biosynthesis of exopolysacchide (vps)
and protein (rbm) components of the biofilm matrix is enhanced by cyclic diguanylate (c‐di …

Global H-NS counter-silencing by LuxR activates quorum sensing gene expression

RR Chaparian, MLN Tran… - Nucleic Acids …, 2020 - academic.oup.com
Bacteria coordinate cellular behaviors using a cell–cell communication system termed
quorum sensing. In Vibrio harveyi, the master quorum sensing transcription factor LuxR …

[HTML][HTML] H-NS: an overarching regulator of the Vibrio cholerae life cycle

JC Ayala, AJ Silva, JA Benitez - Research in microbiology, 2017 - Elsevier
Vibrio cholerae has become a model organism for studies connecting virulence, pathogen
evolution and infectious disease ecology. The coordinate expression of motility, virulence …

H-NS can facilitate specific DNA-binding by RNA polymerase in AT-rich gene regulatory regions

SS Singh, DC Grainger - PLoS genetics, 2013 - journals.plos.org
Extremely AT-rich DNA sequences present a challenging template for specific recognition by
RNA polymerase. In bacteria, this is because the promoter− 10 hexamer, the major DNA …

Spatial organization of DNA sequences directs the assembly of bacterial chromatin by a nucleoid-associated protein

A Japaridze, S Renevey, P Sobetzko, L Stoliar… - Journal of Biological …, 2017 - ASBMB
Structural differentiation of bacterial chromatin depends on cooperative binding of abundant
nucleoid-associated proteins at numerous genomic DNA sites and stabilization of distinct …

Evidence for Two Different Regulatory Mechanisms Linking Replication and Segregation of Vibrio cholerae Chromosome II

T Venkova-Canova, JH Baek, PC FitzGerald… - PLoS …, 2013 - journals.plos.org
Understanding the mechanisms that coordinate replication initiation with subsequent
segregation of chromosomes is an important biological problem. Here we report two …