Interferon-induced transmembrane proteins (IFITMs) are broad spectrum antiviral factors that
inhibit the entry of a wide range of clinically important pathogens including influenza A virus …

The Hedgehog (Hh) pathway is a signaling cascade that plays a crucial role in many
fundamental processes, including embryonic development and tissue homeostasis …

Chimeric antigen receptor T cells (CAR-Ts) have remarkable efficacy in liquid tumors, but
limited responses in solid tumors. We conducted a Phase I trial (NCT02107963) of GD2 …

Cancer poses a serious health problem in society and is increasingly surpassing
cardiovascular disease as the leading cause of mortality in the United States. Current …

Interferon‐inducible transmembrane (IFITM) proteins are a family of small homologous
proteins, localized in the plasma and endolysosomal membranes, which confer cellular …

Extensive studies of the tumor microenvironment (TME) in the last decade have reformed the
view of cancer as a tumor cell-centric disease. The tumor microenvironment, especially …

Hedgehog–GLI (HH) signaling plays an essential role in embryogenesis and tissue
homeostasis. Aberrant activation of the pathway through mutations or other mechanisms is …

Uncontrolled activation of the Hedgehog/Glioma-associated oncogene (HH/GLI) pathway is
a potent oncogenic driver signal promoting numerous cancer hallmarks such as …

Host responses to tumor cells include tumor suppressing or promoting mechanisms. We
sought to detail the effect of Hedgehog (Hh) pathway inhibition on the composition of the …

The Hedgehog (Hh) signaling pathway is pervasively involved in human malignancies,
making it an effective target for cancer treatment for decades. In addition to its direct role in …