Mechanisms of SARS-CoV-2 transmission and pathogenesis
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) marks
the third highly pathogenic coronavirus to spill over into the human population. SARS-CoV-2 …
the third highly pathogenic coronavirus to spill over into the human population. SARS-CoV-2 …
The molecular virology of coronaviruses
E Hartenian, D Nandakumar, A Lari, M Ly… - Journal of Biological …, 2020 - ASBMB
Few human pathogens have been the focus of as much concentrated worldwide attention as
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19. Its …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19. Its …
[HTML][HTML] SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host defenses
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently identified
coronavirus that causes the respiratory disease known as coronavirus disease 2019 (COVID …
coronavirus that causes the respiratory disease known as coronavirus disease 2019 (COVID …
SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation
Abstract The SARS-CoV-2 non-structural protein 1 (Nsp1), also referred to as the host
shutoff factor, suppresses host innate immune functions. By combining cryo-electron …
shutoff factor, suppresses host innate immune functions. By combining cryo-electron …
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
SARS-CoV-2 infection can cause severe respiratory COVID-19. However, many individuals
present with isolated upper respiratory symptoms, suggesting potential to constrain viral …
present with isolated upper respiratory symptoms, suggesting potential to constrain viral …
SARS-CoV-2 uses a multipronged strategy to impede host protein synthesis
The coronavirus SARS-CoV-2 is the cause of the ongoing pandemic of COVID-19.
Coronaviruses have developed a variety of mechanisms to repress host mRNA translation to …
Coronaviruses have developed a variety of mechanisms to repress host mRNA translation to …
[HTML][HTML] Innate immune evasion by human respiratory RNA viruses
M Kikkert - Journal of innate immunity, 2020 - karger.com
The impact of respiratory virus infections on the health of children and adults can be very
significant. Yet, in contrast to most other childhood infections as well as other viral and …
significant. Yet, in contrast to most other childhood infections as well as other viral and …
[HTML][HTML] In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age
Despite limited genomic diversity, severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has shown a wide range of clinical manifestations in different patient populations …
CoV-2) has shown a wide range of clinical manifestations in different patient populations …
Host factors in coronavirus replication
AH De Wilde, EJ Snijder, M Kikkert… - Roles of host gene and …, 2018 - Springer
Coronaviruses are pathogens with a serious impact on human and animal health. They
mostly cause enteric or respiratory disease, which can be severe and life threatening, eg, in …
mostly cause enteric or respiratory disease, which can be severe and life threatening, eg, in …
SARS and MERS: recent insights into emerging coronaviruses
E De Wit, N Van Doremalen, D Falzarano… - Nature reviews …, 2016 - nature.com
Abstract The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in
2012 marked the second introduction of a highly pathogenic coronavirus into the human …
2012 marked the second introduction of a highly pathogenic coronavirus into the human …