[HTML][HTML] A high affinity switch for cAMP in the HCN pacemaker channels

A Porro, A Saponaro, R Castelli, B Introini… - Nature …, 2024 - nature.com
Binding of cAMP to Hyperpolarization activated cyclic nucleotide gated (HCN) channels
facilitates pore opening. It is unclear why the isolated cyclic nucleotide binding domain …