Regulated cell death is a major mechanism to eliminate damaged, infected, or superfluous
cells. Previously, apoptosis was thought to be the only regulated cell death mechanism; …

Abstract α1-Antitrypsin deficiency (A1ATD) is an inherited disorder caused by mutations in
SERPINA1, leading to liver and lung disease. It is not a rare disorder but frequently goes …

Airway neutrophilia is a common feature of many chronic inflammatory lung diseases and is
associated with disease progression, often regardless of the initiating cause. Neutrophils …

Markers of oxidative stress are increased in chronic obstructive pulmonary disease (COPD)
and reactive oxygen species (ROS) are able to alter biological molecules, signaling …

Introduction Chronic obstructive pulmonary disease (COPD) is a progressive disorder that
makes the breathing difficult and is characterized by pathological conditions ranging from …

α1-Antitrypsin (AAT) is the archetype member of the serine protease inhibitor (SERPIN)
supergene family. The AAT deficiency is most often associated with the Z mutation, which …

Abstract Alpha‐1 antitrypsin (AAT) deficiency is an under‐recognized hereditary disorder
associated with the premature onset of chronic obstructive pulmonary disease, liver cirrhosis …

The mechanisms involved in the genesis of chronic obstructive pulmonary disease (COPD)
are poorly defined. This area is complicated and difficult to model because COPD consists of …

The rationale of α1-antitrypsin (AAT) augmentation therapy to treat progressive emphysema
in AAT-deficient patients is based on inhibition of neutrophil elastase; however, the benefit of …

Hereditary deficiency of the protein α-1 antitrypsin (AAT) causes a chronic lung disease in
humans that is characterized by excessive mobilization of neutrophils into the lung …