While mechanobiological processes employ diverse mechanisms, at their heart are force-
induced perturbations in the structure and dynamics of molecules capable of triggering …

Publisher Summary This chapter describes the crystallographic analyses of the
Mycobacterium tuberculosis mechanosensitive channels of large (MscL) and the …

Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …

General principles in biology have often been elucidated from the study of bacteria. This is
true for the bacterial mechanosensitive channel of large conductance, MscL, the channel …

Mechanosensitive (MS) ion channels are membrane proteins that detect and respond to
membrane tension in all branches of life. In bacteria, MS channels prevent cells from lysing …

Mechanosensitive ion channels, which convert external mechanical forces into electrical
and chemical signals in cells, are diverse. Presently, there is no known common sequence …

The tension-driven gating process of MscL from Mycobacterium tuberculosis, Tb-MscL, has
been addressed at near-atomic detail using coarse-grained molecular dynamics …

Ion channels of high conductance (> 200 pS) are widespread among prokaryotes and
eukaryotes. Two examples, the Escherichia coli mechanosensitive ion channels Ec-MscS …

COOH-terminal (S3) domains are conserved within the MscL family of bacterial
mechanosensitive channels, but their function remains unclear. The X-ray structure of MscL …

Total chemical protein synthesis was used to generate multimilligram quantities of the
mechanosensitive channel of large conductance from Escherichia coli (Ec-MscL) and …