Anaplasma phagocytophilum—a widespread multi-host pathogen with highly adaptive strategies
S Stuen, EG Granquist, C Silaghi - Frontiers in cellular and infection …, 2013 - frontiersin.org
The bacterium Anaplasma phagocytophilum has for decades been known to cause the
disease tick-borne fever (TBF) in domestic ruminants in Ixodes ricinus-infested areas in …
disease tick-borne fever (TBF) in domestic ruminants in Ixodes ricinus-infested areas in …
Mechanisms of obligatory intracellular infection with Anaplasma phagocytophilum
Y Rikihisa - Clinical microbiology reviews, 2011 - Am Soc Microbiol
Anaplasma phagocytophilum persists in nature by cycling between mammals and ticks.
Human infection by the bite of an infected tick leads to a potentially fatal emerging disease …
Human infection by the bite of an infected tick leads to a potentially fatal emerging disease …
Lipid hijacking: a unifying theme in vector-borne diseases
Vector-borne illnesses comprise a significant portion of human maladies, representing 17%
of global infections. Transmission of vector-borne pathogens to mammals primarily occurs …
of global infections. Transmission of vector-borne pathogens to mammals primarily occurs …
Anaplasma phagocytophilum and Ehrlichia chaffeensis type IV secretion and Ank proteins
Y Rikihisa, M Lin - Current opinion in microbiology, 2010 - Elsevier
The obligatory intracellular bacterial pathogens Anaplasma and Ehrlichia infect leukocytes
by hijacking host-cell components and processes. The type IV secretion system is up …
by hijacking host-cell components and processes. The type IV secretion system is up …
Hijacking and use of host lipids by intracellular pathogens
Summary “Lipids” is the inclusive name for a complex group of molecules composed
predominantly of carbon, hydrogen, and oxygen (also nitrogen and phosphorus) that are …
predominantly of carbon, hydrogen, and oxygen (also nitrogen and phosphorus) that are …
Molecular events involved in cellular invasion by Ehrlichia chaffeensis and Anaplasma phagocytophilum
Y Rikihisa - Veterinary parasitology, 2010 - Elsevier
Ehrlichia chaffeensis and Anaplasma phagocytophilum are obligatory intracellular bacteria
that preferentially replicate inside leukocytes by utilizing biological compounds and …
that preferentially replicate inside leukocytes by utilizing biological compounds and …
Bacterial colonization of host cells in the absence of cholesterol
SD Gilk, DC Cockrell, C Luterbach, B Hansen… - PLoS …, 2013 - journals.plos.org
Reports implicating important roles for cholesterol and cholesterol-rich lipid rafts in host-
pathogen interactions have largely employed sterol sequestering agents and biosynthesis …
pathogen interactions have largely employed sterol sequestering agents and biosynthesis …
Anaplasma phagocytophilum hijacks flotillin and NPC1 complex to acquire intracellular cholesterol for proliferation, which can be inhibited with ezetimibe
The intracellular cholesterol transport protein Niemann-Pick type C1 (NPC1) and lipid-raft
protein flotillin (FLOT) are required for cholesterol uptake by the obligatory intracellular …
protein flotillin (FLOT) are required for cholesterol uptake by the obligatory intracellular …
Cholesterol-Dependent Anaplasma phagocytophilum Exploits the Low-Density Lipoprotein Uptake Pathway
In eukaryotes, intracellular cholesterol homeostasis and trafficking are tightly regulated.
Certain bacteria, such as Anaplasma phagocytophilum, also require cholesterol; it is …
Certain bacteria, such as Anaplasma phagocytophilum, also require cholesterol; it is …
[HTML][HTML] Breaking in and grabbing a meal: Anaplasma phagocytophilum cellular invasion, nutrient acquisition, and promising tools for their study
HK Truchan, D Seidman, JA Carlyon - Microbes and Infection, 2013 - Elsevier
Anaplasma phagocytophilum invades neutrophils to cause the emerging infection, human
granulocytic anaplasmosis. Here, we provide a focused review of the A. phagocytophilum …
granulocytic anaplasmosis. Here, we provide a focused review of the A. phagocytophilum …