[HTML][HTML] Neuroimaging in schizophrenia: an overview of findings and their implications for synaptic changes
OD Howes, C Cummings, GE Chapman… - …, 2023 - nature.com
Over the last five decades, a large body of evidence has accrued for structural and metabolic
brain alterations in schizophrenia. Here we provide an overview of these findings, focusing …
brain alterations in schizophrenia. Here we provide an overview of these findings, focusing …
Mechanisms underlying dorsolateral prefrontal cortex contributions to cognitive dysfunction in schizophrenia
Kraepelin, in his early descriptions of schizophrenia (SZ), characterized the illness as having
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …
[HTML][HTML] Mapping neurotransmitter systems to the structural and functional organization of the human neocortex
Neurotransmitter receptors support the propagation of signals in the human brain. How
receptor systems are situated within macro-scale neuroanatomy and how they shape …
receptor systems are situated within macro-scale neuroanatomy and how they shape …
Comprehensive functional genomic resource and integrative model for the human brain
INTRODUCTION Strong genetic associations have been found for a number of psychiatric
disorders. However, understanding the underlying molecular mechanisms remains …
disorders. However, understanding the underlying molecular mechanisms remains …
Validity and utility of hierarchical taxonomy of psychopathology (HiTOP): I. Psychosis superspectrum
The Hierarchical Taxonomy of Psychopathology (HiTOP) is a scientific effort to address
shortcomings of traditional mental disorder diagnoses, which suffer from arbitrary …
shortcomings of traditional mental disorder diagnoses, which suffer from arbitrary …
Evaluation of brain-body health in individuals with common neuropsychiatric disorders
Importance Physical health and chronic medical comorbidities are underestimated,
inadequately treated, and often overlooked in psychiatry. A multiorgan, systemwide …
inadequately treated, and often overlooked in psychiatry. A multiorgan, systemwide …
Evidence for embracing normative modeling
In this work, we expand the normative model repository introduced in Rutherford et al.,
2022a to include normative models charting lifespan trajectories of structural surface area …
2022a to include normative models charting lifespan trajectories of structural surface area …
Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3–90 years
Delineating the association of age and cortical thickness in healthy individuals is critical
given the association of cortical thickness with cognition and behavior. Previous research …
given the association of cortical thickness with cognition and behavior. Previous research …
[HTML][HTML] ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries
This review summarizes the last decade of work by the ENIGMA (E nhancing N euro I
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …
The polygenic architecture of schizophrenia—rethinking pathogenesis and nosology
Schizophrenia is a severe psychiatric disorder with considerable morbidity and mortality.
Although the past two decades have seen limited improvement in the treatment of …
Although the past two decades have seen limited improvement in the treatment of …