Heterochromatin mediates many diverse functions in the cell nucleus, including centromere
function, gene silencing and nuclear organization. The condensed structure of …

The regulation of gene expression during thymocyte development provides an ideal
experimental system to study lineage-commitment processes. In particular, expression of the …

Genetic and biochemical de-regulation of Wnt signaling is correlated with breast and other
cancers. Our goal was to identify compounds that block Wnt signaling as a first step toward …

In certain cancers, constitutive Wnt signaling results from mutation in one or more pathway
components. The result is the accumulation and nuclear localization of β‐catenin, which …

Microsatellites are common repeated sequences, which are useful as genetic markers and
lack any clearly established function. In a previous study we suggested that an intronic …

Mechanisms that inhibit cell cycle progression and establish growth arrest are fundamental
to tumor suppression and to normal cell differentiation. A complete understanding of these …

Much of what we know about the role of epigenetics in the determination of phenotype has
come from studies of inbred mice. Some unusual expression patterns arising from …

Abstract HMG box protein 1 (HBP1) is a transcription factor and a potent cell cycle inhibitor
in normal and cancer cells. HBP1 activates or represses the expression of different cell cycle …

This study was aimed at the investigation of the effects of miR‐21 on drug resistance,
invasion, migration, and epithelial–mesenchymal transition (EMT) of lung adenocarcinoma …

The activity of DNA methyltransferase 1 (DNMT1) is associated with diverse biological
activities, including cell proliferation, senescence, and cancer development. In this study, we …