[HTML][HTML] The genetic basis of major depressive disorder

J Flint - Molecular psychiatry, 2023 - nature.com
The genetic dissection of major depressive disorder (MDD) ranks as one of the success
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …

Pleiotropy and cross-disorder genetics among psychiatric disorders

PH Lee, YCA Feng, JW Smoller - Biological psychiatry, 2021 - Elsevier
Genome-wide analyses of common and rare genetic variations have documented the
heritability of major psychiatric disorders, established their highly polygenic genetic …

Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies

MA Waszczuk, KG Jonas, M Bornovalova, G Breen… - Molecular …, 2023 - nature.com
Genome-wide association studies (GWAS) provide biological insights into disease onset
and progression and have potential to produce clinically useful biomarkers. A growing body …

[HTML][HTML] Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits

J Martin, EA Khramtsova, SB Goleva, GAM Blokland… - Biological …, 2021 - Elsevier
Background The origin of sex differences in prevalence and presentation of neuropsychiatric
and behavioral traits is largely unknown. Given established genetic contributions and …

[HTML][HTML] Genome-wide association study of musical beat synchronization demonstrates high polygenicity

M Niarchou, DE Gustavson… - Nature Human …, 2022 - nature.com
Moving in synchrony to the beat is a fundamental component of musicality. Here we
conducted a genome-wide association study to identify common genetic variants associated …

[HTML][HTML] How genetic analysis may contribute to the understanding of avoidant/restrictive food intake disorder (ARFID)

HL Kennedy, L Dinkler, MA Kennedy, CM Bulik… - Journal of Eating …, 2022 - Springer
Avoidant/restrictive food intake disorder (ARFID) was introduced in the fifth edition of the
Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Unlike anorexia nervosa …

Multiple measures of depression to enhance validity of major depressive disorder in the UK Biobank

KP Glanville, JRI Coleman, DM Howard, O Pain… - BJPsych …, 2021 - cambridge.org
BackgroundThe UK Biobank contains data with varying degrees of reliability and
completeness for assessing depression. A third of participants completed a Mental Health …

Shared genetic architecture across psychiatric disorders

AD Grotzinger - Psychological medicine, 2021 - cambridge.org
Psychiatric disorders overlap substantially at the genetic level, with family-based methods
long pointing toward transdiagnostic risk pathways. Psychiatric genomics has progressed …

[HTML][HTML] Exploring the genetic heterogeneity in major depression across diagnostic criteria

BS Jermy, KP Glanville, JRI Coleman, CM Lewis… - Molecular …, 2021 - nature.com
Major depressive disorder (MDD) is defined differently across genetic research studies and
this may be a key source of heterogeneity. While previous literature highlights differences …

[HTML][HTML] Investigating direct and indirect genetic effects in attention-deficit/hyperactivity disorder using parent-offspring trios

J Martin, M Wray, SS Agha, KJS Lewis, RJL Anney… - Biological …, 2023 - Elsevier
Background Attention-deficit/hyperactivity disorder (ADHD) is highly heritable, but little is
known about the relative effects of transmitted (ie, direct) and nontransmitted (ie, indirect) …