[HTML][HTML] The genetic basis of major depressive disorder
J Flint - Molecular psychiatry, 2023 - nature.com
The genetic dissection of major depressive disorder (MDD) ranks as one of the success
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …
Pleiotropy and cross-disorder genetics among psychiatric disorders
Genome-wide analyses of common and rare genetic variations have documented the
heritability of major psychiatric disorders, established their highly polygenic genetic …
heritability of major psychiatric disorders, established their highly polygenic genetic …
Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies
Genome-wide association studies (GWAS) provide biological insights into disease onset
and progression and have potential to produce clinically useful biomarkers. A growing body …
and progression and have potential to produce clinically useful biomarkers. A growing body …
[HTML][HTML] Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits
Background The origin of sex differences in prevalence and presentation of neuropsychiatric
and behavioral traits is largely unknown. Given established genetic contributions and …
and behavioral traits is largely unknown. Given established genetic contributions and …
[HTML][HTML] Genome-wide association study of musical beat synchronization demonstrates high polygenicity
M Niarchou, DE Gustavson… - Nature Human …, 2022 - nature.com
Moving in synchrony to the beat is a fundamental component of musicality. Here we
conducted a genome-wide association study to identify common genetic variants associated …
conducted a genome-wide association study to identify common genetic variants associated …
[HTML][HTML] How genetic analysis may contribute to the understanding of avoidant/restrictive food intake disorder (ARFID)
Avoidant/restrictive food intake disorder (ARFID) was introduced in the fifth edition of the
Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Unlike anorexia nervosa …
Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Unlike anorexia nervosa …
Multiple measures of depression to enhance validity of major depressive disorder in the UK Biobank
BackgroundThe UK Biobank contains data with varying degrees of reliability and
completeness for assessing depression. A third of participants completed a Mental Health …
completeness for assessing depression. A third of participants completed a Mental Health …
Shared genetic architecture across psychiatric disorders
AD Grotzinger - Psychological medicine, 2021 - cambridge.org
Psychiatric disorders overlap substantially at the genetic level, with family-based methods
long pointing toward transdiagnostic risk pathways. Psychiatric genomics has progressed …
long pointing toward transdiagnostic risk pathways. Psychiatric genomics has progressed …
[HTML][HTML] Exploring the genetic heterogeneity in major depression across diagnostic criteria
BS Jermy, KP Glanville, JRI Coleman, CM Lewis… - Molecular …, 2021 - nature.com
Major depressive disorder (MDD) is defined differently across genetic research studies and
this may be a key source of heterogeneity. While previous literature highlights differences …
this may be a key source of heterogeneity. While previous literature highlights differences …
[HTML][HTML] Investigating direct and indirect genetic effects in attention-deficit/hyperactivity disorder using parent-offspring trios
Background Attention-deficit/hyperactivity disorder (ADHD) is highly heritable, but little is
known about the relative effects of transmitted (ie, direct) and nontransmitted (ie, indirect) …
known about the relative effects of transmitted (ie, direct) and nontransmitted (ie, indirect) …