Big data is transforming biomedical research by integrating massive amounts of data from
laboratory experiments, clinical investigations, healthcare records, and the internet of things …

Protein-protein interactions (PPIs) are a key component of the subcellular molecular
networks which enable cells to function. Due to their importance in homeostasis, alterations …

Induced pluripotent stem cell (iPSC)-derived dopamine neurons provide an opportunity to
model Parkinson's disease (PD), but neuronal cultures are confounded by asynchronous …

Neurodegenerative proteinopathies are characterized by progressive cell loss that is
preceded by the mislocalization and aberrant accumulation of proteins prone to …

Abstract Background Circular RNAs (circRNAs) is a newly discovered non-coding RNA that
can be used as biomarkers in clinical blood samples. This study aims to screen differentially …

Dysregulation of calcium signaling is emerging as a key feature in the pathogenesis of
neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD) …

Synucleinopathies are a group of neurodegenerative disorders characterized by pathologic
aggregates of neural and glial α-synuclein (α-syn) in the form of Lewy bodies (LBs), Lewy …

Abstract Parkinson's disease (PD), the second most prevalent neurodegenerative disorder,
is projected to see a significant rise in incidence over the next three decades. The precise …

Abstract Purpose of Review Parkinson's disease (PD) is the second most common
neurodegenerative disorder affecting older individuals. The specific cause underlying …

The development of drug resistance is one of the main causes of failure in anti-cancer
treatments. Tumor cells adopt many strategies to counteract the action of chemotherapeutic …