[HTML][HTML] Mast cells as a unique hematopoietic lineage and cell system: from Paul Ehrlich's visions to precision medicine concepts

P Valent, C Akin, K Hartmann, G Nilsson, A Reiter… - Theranostics, 2020 - ncbi.nlm.nih.gov
The origin and functions of mast cells (MCs) have been debated since their description by
Paul Ehrlich in 1879. MCs have long been considered'reactive bystanders' and'amplifiers' in …

The role of myeloid cells in the promotion of tumour angiogenesis

C Murdoch, M Muthana, SB Coffelt, CE Lewis - Nature reviews cancer, 2008 - nature.com
The use of various transgenic mouse models and analysis of human tumour biopsies has
shown that bone marrow-derived myeloid cells, such as macrophages, neutrophils …

[引用][C] DeVita, Hellman, and Rosenberg's cancer: principles & practice of oncology

VT DeVita - 2008 - books.google.com
Acclaimed by the worldwide medical community as" a staple reference text in the medical
oncologist's library"(JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and …

The inflammatory response in myocardial infarction

NG Frangogiannis, CW Smith… - Cardiovascular …, 2002 - academic.oup.com
One of the major therapeutic goals of modern cardiology is to design strategies aimed at
minimizing myocardial necrosis and optimizing cardiac repair following myocardial …

KIT as a master regulator of the mast cell lineage

M Tsai, P Valent, SJ Galli - Journal of Allergy and Clinical Immunology, 2022 - Elsevier
The discovery in 1987/1988 and 1990 of the cell surface receptor KIT and its ligand, stem
cell factor (SCF), was a critical achievement in efforts to understand the development and …

Stem cell factor and hematopoiesis

VC Broudy - Blood, The Journal of the American Society of …, 1997 - ashpublications.org
Stem cell factor (SCF; also known as kit ligand, mast cell ultimate destinations during
development. Hematopoietic cells growth factor, or steel factor) is a hematopoietic cytokine …

Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT

P Dubreuil, S Letard, M Ciufolini, L Gros, M Humbert… - PloS one, 2009 - journals.plos.org
Background The stem cell factor receptor, KIT, is a target for the treatment of cancer,
mastocytosis, and inflammatory diseases. Here, we characterise the in vitro and in vivo …

[HTML][HTML] The biology of stem cell factor and its receptor C-kit

LK Ashman - The international journal of biochemistry & cell biology, 1999 - Elsevier
The receptor tyrosine kinase c-Kit and its ligand Stem Cell Factor (SCF) are essential for
haemopoiesis, melanogenesis and fertility. SCF acts at multiple levels of the haemopoietic …

c-kit Ligand and Flt3 Ligand: Stem/Progenitor Cell Factors With Overlapping Yet Distinct Activities

SD Lyman, SEW Jacobsen - … Journal of the American Society of …, 1998 - ashpublications.org
HEMATOPOIESIS IS A life-long process responsible for replenishing both hematopoietic
progenitor cells and mature blood cells from a pool of pluripotent, long-term reconstituting …

Mast cell ontogeny: From fetal development to life‐long health and disease

SL Chia, S Kapoor, C Carvalho… - Immunological …, 2023 - Wiley Online Library
Mast cells (MCs) are evolutionarily ancient innate immune cells with important roles in
protective immunity against bacteria, parasites, and venomous animals. They can be found …