[HTML][HTML] Endothelial dysfunction and immunothrombosis in sepsis
E Maneta, E Aivalioti, S Tual-Chalot… - Frontiers in …, 2023 - frontiersin.org
Sepsis is a life-threatening clinical syndrome characterized by multiorgan dysfunction
caused by a dysregulated or over-reactive host response to infection. During sepsis, the …
caused by a dysregulated or over-reactive host response to infection. During sepsis, the …
Clinical promise of next-generation complement therapeutics
The complement system plays a key role in pathogen immunosurveillance and tissue
homeostasis. However, subversion of its tight regulatory control can fuel a vicious cycle of …
homeostasis. However, subversion of its tight regulatory control can fuel a vicious cycle of …
[HTML][HTML] Eculizumab as an emergency treatment for adult patients with severe COVID-19 in the intensive care unit: a proof-of-concept study
D Annane, N Heming, L Grimaldi-Bensouda… - …, 2020 - thelancet.com
Background Complement pathway inhibition may provide benefit for severe acute
respiratory illnesses caused by viral infections such as COVID-19. We present results from a …
respiratory illnesses caused by viral infections such as COVID-19. We present results from a …
Sepsis therapies: learning from 30 years of failure of translational research to propose new leads
Sepsis has been identified by the World Health Organization (WHO) as a global health
priority. There has been a tremendous effort to decipher underlying mechanisms …
priority. There has been a tremendous effort to decipher underlying mechanisms …
Therapeutic targeting of the complement system: from rare diseases to pandemics
P Garred, AJ Tenner, TE Mollnes - Pharmacological reviews, 2021 - ASPET
The complement system was discovered at the end of the 19th century as a heat-labile
plasma component that “complemented” the antibodies in killing microbes, hence the name …
plasma component that “complemented” the antibodies in killing microbes, hence the name …
[HTML][HTML] The SARS-coronavirus infection cycle: a survey of viral membrane proteins, their functional interactions and pathogenesis
NA Wong, MH Saier Jr - International journal of molecular sciences, 2021 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a novel epidemic
strain of Betacoronavirus that is responsible for the current viral pandemic, coronavirus …
strain of Betacoronavirus that is responsible for the current viral pandemic, coronavirus …
The renaissance of complement therapeutics
D Ricklin, DC Mastellos, ES Reis… - Nature Reviews …, 2018 - nature.com
The increasing number of clinical conditions that involve a pathological contribution from the
complement system—many of which affect the kidneys—has spurred a regained interest in …
complement system—many of which affect the kidneys—has spurred a regained interest in …
The role of endothelial shear stress on haemodynamics, inflammation, coagulation and glycocalyx during sepsis
F Lupu, G Kinasewitz, K Dormer - Journal of cellular and …, 2020 - Wiley Online Library
Sepsis is a multifactorial syndrome primarily determined by the host response to an invading
pathogen. It is common, with over 48 million cases worldwide in 2017, and often lethal. The …
pathogen. It is common, with over 48 million cases worldwide in 2017, and often lethal. The …
[PDF][PDF] The role of complement in liver injury, regeneration, and transplantation
EB Thorgersen, A Barratt‐Due, H Haugaa… - …, 2019 - Wiley Online Library
The liver is both an immunologically complex and a privileged organ. The innate immune
system is a central player, in which the complement system emerges as a pivotal part of liver …
system is a central player, in which the complement system emerges as a pivotal part of liver …
[HTML][HTML] Immunotherapy in sepsis-brake or accelerate?
F Steinhagen, SV Schmidt, JC Schewe… - Pharmacology & …, 2020 - Elsevier
Sepsis, a life threating syndrome characterized by organ failure after infection, is the most
common cause of death in hospitalized patients. The treatment of sepsis is generally …
common cause of death in hospitalized patients. The treatment of sepsis is generally …