Microsatellite instability (MSI) is the molecular fingerprint of a deficient mismatch repair
system. Approximately 15% of colorectal cancers (CRC) display MSI owing either to …

The high frequency of phosphoinositide 3-kinase (PI3K) pathway alterations in cancer has
led to a surge in the development of PI3K inhibitors. Many of these targeted therapies are …

The involvement of the PIK3CA gene product p110α, the catalytic subunit of
phosphatidylinositol 3-kinase (PI3K), in human cancer has been suggested for over 15 …

Purpose PIK3CA mutation and subsequent activation of the AKT pathway play an important
role in colorectal carcinogenesis. However, little is known about the prognostic role of …

Abstract Purpose: Mutations in PIK3CA [the gene encoding the p110α catalytic subunit of
phosphatidylinositide-3-kinase (PI3K)] play an important role in colorectal carcinogenesis …

ABSTRACT PI3K/AKT/mTOR signaling pathway is one of the key dysregulated pathways in
different tumor types, including colorectal cancer (CRC). Activation of this pathway is shown …

Purpose: It has been reported that activating KRAS mutations negatively affect response to
anti–epidermal growth factor receptor (EGFR) monoclonal antibodies in metastatic …

Somatic PIK3CA mutations are often present in colorectal cancer. Mutant PIK3CA activates
AKT signaling, which up-regulates fatty acid synthase (FASN). Microsatellite instability (MSI) …

Mutations in PIK3CA are present in 10 to 15% of colorectal carcinomas. We aimed to
examine how PIK3CA mutations relate to other molecular alterations in colorectal …

Colorectal cancer (CRC) is a heterogeneous disease, arising from many possible etiological
pathways. This heterogeneity can have important implications for CRC prognosis and …