Role of oxidative stress in ocular diseases: a balancing act
Redox homeostasis is a delicate balancing act of maintaining appropriate levels of
antioxidant defense mechanisms and reactive oxidizing oxygen and nitrogen species. Any …
antioxidant defense mechanisms and reactive oxidizing oxygen and nitrogen species. Any …
Insights into the biochemical and biophysical mechanisms mediating the longevity of the transparent optics of the eye lens
RA Quinlan, JI Clark - Journal of Biological Chemistry, 2022 - ASBMB
In the human eye, a transparent cornea and lens combine to form the" refracton" to focus
images on the retina. This requires the refracton to have a high refractive index" n," mediated …
images on the retina. This requires the refracton to have a high refractive index" n," mediated …
Extracellular protein homeostasis in neurodegenerative diseases
The protein homeostasis (proteostasis) system encompasses the cellular processes that
regulate protein synthesis, folding, concentration, trafficking and degradation. In the case of …
regulate protein synthesis, folding, concentration, trafficking and degradation. In the case of …
Copper reductase activity and free radical chemistry by cataract-associated human lens γ-crystallins
G Palomino-Vizcaino, N Schuth… - Journal of the …, 2023 - ACS Publications
Cataracts are caused by high-molecular-weight aggregates of human eye lens proteins that
scatter light, causing lens opacity. Metal ions have emerged as important potential players in …
scatter light, causing lens opacity. Metal ions have emerged as important potential players in …
[HTML][HTML] Aging of the eye: Lessons from cataracts and age-related macular degeneration
A Cvekl, J Vijg - Ageing Research Reviews, 2024 - Elsevier
Aging is the greatest risk factor for chronic human diseases, including many eye diseases.
Geroscience aims to understand the effects of the aging process on these diseases …
Geroscience aims to understand the effects of the aging process on these diseases …
Redox chemistry of lens crystallins: A system of cysteines
The nuclear region of the lens is metabolically quiescent, but it is far from inert chemically.
Without cellular renewal and with decades of environmental exposures, the lens proteome …
Without cellular renewal and with decades of environmental exposures, the lens proteome …
Generation of lens progenitor cells and lentoid bodies from pluripotent stem cells: Novel tools for human lens development and ocular disease etiology
A Cvekl, MJ Camerino - Cells, 2022 - mdpi.com
In vitro differentiation of human pluripotent stem cells (hPSCs) into specialized tissues and
organs represents a powerful approach to gain insight into those cellular and molecular …
organs represents a powerful approach to gain insight into those cellular and molecular …
The application of quantitative metabolomics for the taxonomic differentiation of birds
EA Zelentsova, LV Yanshole, YP Tsentalovich… - Biology, 2022 - mdpi.com
Simple Summary Modern evolutionary biology offers a wide variety of methods to explore
the evolution of species and to describe their relationships. The methods of DNA/RNA …
the evolution of species and to describe their relationships. The methods of DNA/RNA …
Adenosine Triphosphate (ATP) and Protein Aggregation in Age-Related Vision-Threatening Ocular Diseases
JV Greiner, T Glonek - Metabolites, 2023 - mdpi.com
Protein aggregation is the etiopathogenesis of the three most profound vision-threatening
eye diseases: age-related cataract, presbyopia, and age-related macular degeneration. This …
eye diseases: age-related cataract, presbyopia, and age-related macular degeneration. This …
α-Crystallin chaperone mimetic drugs inhibit lens γ-crystallin aggregation: Potential role for cataract prevention
Γ-Crystallins play a major role in age-related lens transparency. Their destabilization by
mutations and physical chemical insults are associated with cataract formation. Therefore …
mutations and physical chemical insults are associated with cataract formation. Therefore …