Despite the capacity of chaperones and other homeostatic components to restore folding
equilibrium, cells appear poorly adapted for chronic oxidative stress that increases in cancer …

Mitochondria play a central role in the survival and death of neurons. The detailed
bioenergetic mechanisms by which isolated mitochondria generate ATP, sequester Ca2+ …

Amyloid β-peptide (Aβ) is heavily deposited in the brains of Alzheimer's disease (AD)
patients, and free radical oxidative stress, particularly of neuronal lipids and proteins, is …

Oxidative stress, manifested by protein oxidation, lipid peroxidation, DNA oxidation and 3-
nitrotyrosine formation, among other indices, is observed in Alzheimer's disease (AD) brain …

beta-Amyloid precursor protein (beta-APP), the source of the fibrillogenic amyloid beta-
peptide (A beta) that accumulates in the brain of victims of Alzheimer's disease, is a …

Amyloid β-peptide [Aβ (1–42)] is central to the pathogenesis of Alzheimer's disease (AD),
and the AD brain is under intense oxidative stress, including membrane lipid peroxidation …

Deficiency in repair of nuclear and mitochondrial DNA damage has been linked to several
neurodegenerative disorders. Many recent experimental results indicate that the post-mitotic …

Alzheimer's disease, the major dementing disorder of the elderly that affects over 4 million
Americans, is related to amyloid β-peptide, the principal component of senile plaques in …

Activation of glutamate receptors can trigger the death of neurons and some types of glial
cells, particularly when the cells are coincidentally subjected to adverse conditions such as …

The endoplasmic reticulum (ER) is a morphologically and functionally diverse organelle
capable of integrating multiple extracellular and internal signals and generating adaptive …