Endogenous cytoplasmic DNA (cytoDNA) species are emerging as key mediators of
inflammation in diverse physiological and pathological contexts. Although the role of …

During almost 40 years of use, the micronucleus assay (MN) has become one of the most
popular methods to assess genotoxicity of different chemical and physical factors, including …

The terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay
detects DNA breakage by labeling the free 3ʹ-hydroxyl termini. Given that genomic DNA …

This review describes the cytokinesis-block micronucleus (CBMN) cytome assay and its
evolution into a molecular cytogenetic method of chromosomal instability (CIN). Micronuclei …

Abstract The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9
nuclease system has allowed the generation of disease models and the development of …

Cancer research has traditionally focused on the characterization of individual molecular
mechanisms that can contribute to cancer. Due to the multiple levels of genomic and non …

Tumors arise from the transformation of normal stem cells or mature somatic cells.
Intriguingly, two types of tumors have been observed by pathologists for centuries: well …

Cancer is a disease of altered signaling and metabolism, causing uncontrolled division and
survival of transformed cells. A host of molecules, factors, and conditions have been …

In recent years, the classification of adult-type diffuse gliomas has undergone a revolution,
wherein specific molecular features now represent defining diagnostic criteria of IDH-wild …

Chromosome instability (CIN) refers to an ongoing rate of chromosomal changes and is a
driver of genetic, cell-to-cell heterogeneity. It is an aberrant phenotype that is intimately …