Synaptic effects induced by alcohol

DM Lovinger, M Roberto - 2023 - Springer
Ethanol (EtOH) has effects on numerous cellular molecular targets, and alterations in
synaptic function are prominent among these effects. Acute exposure to EtOH activates or …

Amygdala and bed nucleus of the stria terminalis circuitry: implications for addiction-related behaviors

AM Stamatakis, DR Sparta, JH Jennings… - …, 2014 - Elsevier
Complex motivated behavioral processes, such as those that can go awry following
substance abuse and other neuropsychiatric disorders, are mediated by a distributive …

Effects of chronic ethanol exposure on neuronal function in the prefrontal cortex and extended amygdala

KE Pleil, EG Lowery-Gionta, NA Crowley, C Li… - …, 2015 - Elsevier
Chronic alcohol consumption and withdrawal leads to anxiety, escalated alcohol drinking
behavior, and alcohol dependence. Alterations in the function of key structures within the …

NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking

KE Pleil, JA Rinker, EG Lowery-Gionta… - Nature …, 2015 - nature.com
Binge alcohol drinking is a tremendous public health problem because it leads to the
development of numerous pathologies, including alcohol abuse and anxiety. It is thought to …

The intersection of stress and reward: BNST modulation of aversive and appetitive states

S Ch'ng, J Fu, RM Brown, SJ McDougall… - Progress in Neuro …, 2018 - Elsevier
The bed nucleus of the stria terminalis (BNST) is widely acknowledged as a brain structure
that regulates stress and anxiety states, as well as aversive and appetitive behaviours. The …

[HTML][HTML] The role of Neuropeptide Y in fear conditioning and extinction

RO Tasan, D Verma, J Wood, G Lach, B Hörmer… - Neuropeptides, 2016 - Elsevier
While anxiety disorders are the brain disorders with the highest prevalence and constitute a
major burden for society, a considerable number of affected people are still treated …

[HTML][HTML] Neuropeptide regulation of signaling and behavior in the BNST

TL Kash, KE Pleil, CA Marcinkiewcz… - Molecules and cells, 2015 - Elsevier
Recent technical developments have transformed how neuroscientists can probe brain
function. What was once thought to be difficult and perhaps impossible, stimulating a single …

Neuronal diversity of the amygdala and the bed nucleus of the stria terminalis

A Beyeler, J Dabrowska - Handbook of behavioral neuroscience, 2020 - Elsevier
The amygdala complex is a diverse group of more than 13 nuclei, segregated in five major
groups: the basolateral (BLA), central (CeA), medial (MeA), cortical (CoA), and basomedial …

Role of the bed nucleus of the stria terminalis in PTSD: insights from preclinical models

OW Miles, S Maren - Frontiers in behavioral neuroscience, 2019 - frontiersin.org
Post-traumatic stress disorder (PTSD) afflicts approximately 8% of the United States
population and represents a significant public health burden, but the underlying neural …

Multi-omics analysis identifies mitochondrial pathways associated with anxiety-related behavior

Z Misiewicz, S Iurato, N Kulesskaya, L Salminen… - PLoS …, 2019 - journals.plos.org
Stressful life events are major environmental risk factors for anxiety disorders, although not
all individuals exposed to stress develop clinical anxiety. The molecular mechanisms …