The discovery of cis-platin and its second and third generation analogues created a hope in
cancer chemotherapy. Cis-platin and its second generation analogue carboplatin have been …

DNA is stored in a highly compact, condensed phase in viruses, bacteria and eukaryotes.
Co (NH 3) 6 3+ is a well-known inorganic cation that can induce DNA condensation, and …

Metals have been considered for millennia to have medicinal values. With the advent of
modern medicine, many metal-based drugs have proven to be highly effective in the clinic …

The development of the trinuclear platinum (II) complex BBR3464 (also known as triplatin) in
the late 1990s was meant to be a revolution in the field of platinum chemotherapy. What …

The dynamic topological states of chromosomal DNA regulate many cellular fundamental
processes universally in all three domains of life, that is, bacteria, archaea, and eukaryotes …

The presented work, submitted as a paper, deals with the substitution reactions of
mononuclear and dinuclear platinum (II) complexes of di‐2‐pyridylaminodiaquaplatinum …

Cisplatin is the main platinum antitumor drug applied in clinical settings. However, its trans
isomer, transplatin, is known to have an ineffective antitumor activity. Despite intensive …

Aim: This study aimed to characterize the cellular basis of the platinum cytotoxicity of two
novel platinum complexes, 3Pt and 1Pt, in comparison with that of cisplatin. 3Pt comprises …

Background: Drug design and discovery studies still remain of great importance in the
search for more convenient chemotherapeutic to avoid the drug resistance, systemic toxicity …

The discovery of cis-platin in the treatment of cancer there has been a considerable
exploration on the antitumoral activity of other transition metal complexes. One of the main …