Functions of murine dendritic cells
V Durai, KM Murphy - Immunity, 2016 - cell.com
Dendritic cells (DCs) play critical roles in activating innate immune cells and initiating
adaptive immune responses. The functions of DCs were originally obscured by their overlap …
adaptive immune responses. The functions of DCs were originally obscured by their overlap …
T cell-mediated immunity to malaria
Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …
Liver-resident memory CD8+ T cells form a front-line defense against malaria liver-stage infection
In recent years, various intervention strategies have reduced malaria morbidity and mortality,
but further improvements probably depend upon development of a broadly protective …
but further improvements probably depend upon development of a broadly protective …
The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation
Immune-modulating therapies have revolutionized the treatment of chronic diseases,
particularly cancer. However, their success is restricted and there is a need to identify new …
particularly cancer. However, their success is restricted and there is a need to identify new …
Malaria prevention: from immunological concepts to effective vaccines and protective antibodies
IA Cockburn, RA Seder - Nature immunology, 2018 - nature.com
Abstract Development of a malaria vaccine remains a critical priority to decrease clinical
disease and mortality and facilitate eradication. Accordingly, RTS, S, a protein-subunit …
disease and mortality and facilitate eradication. Accordingly, RTS, S, a protein-subunit …
[HTML][HTML] Adrenergic regulation of the vasculature impairs leukocyte interstitial migration and suppresses immune responses
The sympathetic nervous system (SNS) controls various physiological functions via the
neurotransmitter noradrenaline. Activation of the SNS in response to psychological or …
neurotransmitter noradrenaline. Activation of the SNS in response to psychological or …
CD8+ T cell activation leads to constitutive formation of liver tissue-resident memory T cells that seed a large and flexible niche in the liver
LE Holz, JE Prier, D Freestone, TM Steiner, K English… - Cell reports, 2018 - cell.com
Liver tissue-resident memory T (Trm) cells migrate throughout the sinusoids and are capable
of protecting against malaria sporozoite challenge. To gain an understanding of liver Trm …
of protecting against malaria sporozoite challenge. To gain an understanding of liver Trm …
A natural peptide antigen within the plasmodium ribosomal protein RPL6 confers liver TRM cell-mediated immunity against malaria in mice
AM Valencia-Hernandez, WY Ng, N Ghazanfari… - Cell host & …, 2020 - cell.com
Liver-resident memory CD8+ T (T RM) cells remain in and constantly patrol the liver to elicit
rapid immunity upon antigen encounter and can mediate efficient protection against liver …
rapid immunity upon antigen encounter and can mediate efficient protection against liver …
Activated brain endothelial cells cross-present malaria antigen
SW Howland, CM Poh, L Rénia - PLoS pathogens, 2015 - journals.plos.org
In the murine model of cerebral malaria caused by P. berghei ANKA (PbA), parasite-specific
CD8+ T cells directly induce pathology and have long been hypothesized to kill brain …
CD8+ T cells directly induce pathology and have long been hypothesized to kill brain …
Glycolipid-peptide vaccination induces liver-resident memory CD8+ T cells that protect against rodent malaria
Liver resident-memory CD8+ T cells (TRM cells) can kill liver-stage Plasmodium-infected
cells and prevent malaria, but simple vaccines for generating this important immune …
cells and prevent malaria, but simple vaccines for generating this important immune …