Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy
Epigenetics is dynamic and heritable modifications to the genome that occur independently
of DNA sequence. It requires interactions cohesively with various enzymes and other …
of DNA sequence. It requires interactions cohesively with various enzymes and other …
DNA methylation in health and disease
KD Robertson, AP Wolffe - Nature reviews genetics, 2000 - nature.com
DNA methylation has recently moved to centre stage in the aetiology of human
neurodevelopmental syndromes such as the fragile X, ICF and Rett syndromes. These …
neurodevelopmental syndromes such as the fragile X, ICF and Rett syndromes. These …
Dnmt1 has de novo activity targeted to transposable elements
DNA methylation plays a critical role during development, particularly in repressing
retrotransposons. The mammalian methylation landscape is dependent on the combined …
retrotransposons. The mammalian methylation landscape is dependent on the combined …
Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
M Okano, S Xie, E Li - Nature genetics, 1998 - nature.com
Fig. 1 Sequence alignments, structures and expression patterns of mouse Dnmt3a and
Dnmt3b. a, Sequences of Dnmt3α and Dnmt3β. Identical amino-acid residues are shaded …
Dnmt3b. a, Sequences of Dnmt3α and Dnmt3β. Identical amino-acid residues are shaded …
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B
MicroRNAs (miRNAs) are small, noncoding RNAs that regulate expression of many genes.
Recent studies suggest roles of miRNAs in carcinogenesis. We and others have shown that …
Recent studies suggest roles of miRNAs in carcinogenesis. We and others have shown that …
The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors
KD Robertson, E Uzvolgyi, G Liang… - Nucleic acids …, 1999 - academic.oup.com
DNA methylation in mammals is required for embryonic development, X chromosome
inactivation and imprinting. Previous studies have shown that methylation patterns become …
inactivation and imprinting. Previous studies have shown that methylation patterns become …
DNA methylation, methyltransferases, and cancer
KD Robertson - Oncogene, 2001 - nature.com
The field of epigenetics has recently moved to the forefront of studies relating to diverse
processes such as transcriptional regulation, chromatin structure, genome integrity, and …
processes such as transcriptional regulation, chromatin structure, genome integrity, and …
Recombinant human DNA (cytosine-5) methyltransferase: I. Expression, purification, and comparison of de novo and maintenance methylation
A method is described to express and purify human DNA (cytosine-5) methyltransferase
(human DNMT1) using a protein splicing (intein) fusion partner in a baculovirus expression …
(human DNMT1) using a protein splicing (intein) fusion partner in a baculovirus expression …
DNA methylation
R Singal, GD Ginder - Blood, The Journal of the American …, 1999 - ashpublications.org
SINCE ITS FIRST recognition in 1948, the fifth base of human DNA, 5-methylcytosine (5-mC)
has generated much interest and considerable controversy during attempts to understand its …
has generated much interest and considerable controversy during attempts to understand its …
DNA methylation: past, present and future directions
KD Robertson, P A. Jones - Carcinogenesis, 2000 - academic.oup.com
DNA methylation, or the covalent addition of a methyl group to cytosine within the context of
the CpG dinucleotide, has profound effects on the mammalian genome. These effects …
the CpG dinucleotide, has profound effects on the mammalian genome. These effects …