TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases
M Zhang, Y Ma, X Ye, N Zhang, L Pan… - Signal Transduction and …, 2023 - nature.com
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
[HTML][HTML] Role of IL-6 in the regulation of neuronal development, survival and function
The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial
and destructive potentials. It can exert opposing actions triggering either neuron survival …
and destructive potentials. It can exert opposing actions triggering either neuron survival …
Ultrasound-guided nerve hydrodissection for pain management: rationale, methods, current literature, and theoretical mechanisms
Nerve hydrodissection (HD), a technique used when treating nerve entrapments, involves
the injection of an anesthetic, saline, or 5% dextrose in water to separate the nerve from the …
the injection of an anesthetic, saline, or 5% dextrose in water to separate the nerve from the …
TRPs in pain sensation
I Jardín, JJ López, R Diez, J Sánchez-Collado… - Frontiers in …, 2017 - frontiersin.org
According to the International Association for the Study of Pain (IASP) pain is characterized
as an “unpleasant sensory and emotional experience associated with actual or potential …
as an “unpleasant sensory and emotional experience associated with actual or potential …
Electroacupuncture attenuates CFA-induced inflammatory pain by suppressing Nav1. 8 through S100B, TRPV1, opioid, and adenosine pathways in mice
HY Liao, CL Hsieh, CP Huang, YW Lin - Scientific reports, 2017 - nature.com
Pain is associated with several conditions, such as inflammation, that result from altered
peripheral nerve properties. Electroacupuncture (EA) is a common Chinese clinical medical …
peripheral nerve properties. Electroacupuncture (EA) is a common Chinese clinical medical …
Unlocking the potential of TRPV1 based siRNA therapeutics for the treatment of chemotherapy-induced neuropathic pain
Chemotherapy-induced neuropathic pain (CINP) is among the most common clinical
complications associated with the use of anti-cancer drugs. CINP occurs in nearly 68.1% of …
complications associated with the use of anti-cancer drugs. CINP occurs in nearly 68.1% of …
Mechanisms of acupuncture–electroacupuncture on inflammatory pain
Q Zhang, M Zhou, M Huo, Y Si, Y Zhang… - Molecular …, 2023 - journals.sagepub.com
Acupuncture, as a traditional treatment, has been extensively used in China for thousands of
years. According to the World Health Organization (WHO), acupuncture is recommended for …
years. According to the World Health Organization (WHO), acupuncture is recommended for …
In situ delivery of a curcumin-loaded dynamic hydrogel for the treatment of chronic peripheral neuropathy
Patients with peripheral nerve injuries would highly likely suffer from chronic neuropathic
pain even after surgical intervention. The primary reasons for this involve sustained …
pain even after surgical intervention. The primary reasons for this involve sustained …
Topical treatments and their molecular/cellular mechanisms in patients with peripheral neuropathic pain—narrative review
M Kocot-Kępska, R Zajączkowska, J Mika, DJ Kopsky… - Pharmaceutics, 2021 - mdpi.com
Neuropathic pain in humans results from an injury or disease of the somatosensory nervous
system at the peripheral or central level. Despite the considerable progress in pain …
system at the peripheral or central level. Despite the considerable progress in pain …
The mysteries of capsaicin-sensitive afferents
A fundamental subdivision of nociceptive sensory neurons is named after their unique
sensitivity to capsaicin, the pungent ingredient in hot chili peppers: these are the capsaicin …
sensitivity to capsaicin, the pungent ingredient in hot chili peppers: these are the capsaicin …