Astrocytes in selective vulnerability to neurodegenerative disease

TS Zimmer, AL Orr, AG Orr - Trends in neurosciences, 2024 - cell.com
Selective vulnerability of specific brain regions and cell populations is a hallmark of
neurodegenerative disorders. Mechanisms of selective vulnerability involve neuronal …

A concerted neuron–astrocyte program declines in ageing and schizophrenia

E Ling, J Nemesh, M Goldman, N Kamitaki, N Reed… - Nature, 2024 - nature.com
Human brains vary across people and over time; such variation is not yet understood in
cellular terms. Here we describe a relationship between people's cortical neurons and …

Astrocytes as Drivers and Disruptors of Behavior: New Advances in Basic Mechanisms and Therapeutic Targeting

D Barnett, K Bohmbach, V Grelot, A Charlet… - Journal of …, 2023 - Soc Neuroscience
Astrocytes are emerging as key regulators of cognitive function and behavior. This review
highlights some of the latest advances in the understanding of astrocyte roles in different …

Sleep architecture and vitamin D in hypertensives with obstructive sleep apnea: A polysomnographic study

J Kanclerska, M Wieckiewicz… - Dental and …, 2024 - bazawiedzy.upwr.edu.pl
Background. Obstructive sleep apnea (OSA) and arterial hypertension (AH) are closely
linked disorders with common pathophysiological features. Objectives. The present study …

Norepinephrine Signals Through Astrocytes To Modulate Synapses

KB Lefton, Y Wu, A Yen, T Okuda, Y Zhang, Y Dai… - …, 2024 - pmc.ncbi.nlm.nih.gov
Locus coeruleus (LC)-derived norepinephrine (NE) drives network and behavioral
adaptations to environmental saliencies by reconfiguring circuit connectivity, but the …

Astrocytes: new evidence, new models, new roles

A Brazhe, A Verisokin, D Verveyko, D Postnov - Biophysical Reviews, 2023 - Springer
Astrocytes have been in the limelight of active research for about 3 decades now. Over this
period, ideas about their function and role in the nervous system have evolved from simple …

[HTML][HTML] Astrocytic chloride regulates brain function in health and disease

V Untiet - Cell Calcium, 2024 - Elsevier
Chloride ions (Cl−) play a pivotal role in synaptic inhibition in the central nervous system,
primarily mediated through ionotropic mechanisms. A recent breakthrough emphathizes the …

[HTML][HTML] Lifestyle Factors Counteract the Neurodevelopmental Impact of Genetic Risk for Accelerated Brain Aging in Adolescence

R Petrican, A Fornito, E Boyland - Biological Psychiatry, 2024 - Elsevier
Background The transition from childhood to adolescence is characterized by enhanced
neural plasticity and a consequent susceptibility to both beneficial and adverse aspects of …

[HTML][HTML] Dynamic changes of media prefrontal cortex astrocytic activity in response to negative stimuli in male mice

AM Wu, JY Zhang, WZ Lun, Z Geng, Y Yang, JC Wu… - Neurobiology of …, 2024 - Elsevier
Astrocytes play significant roles in regulating the central stress response. Chronic stress
impairs the structure and function of astrocytes in many brain regions such as media …

Cortical norepinephrine-astrocyte signaling critically mediates learned behavior

GT Drummond, A Natesan, M Celotto, J Shih, P Ojha… - bioRxiv, 2024 - biorxiv.org
Updating behavior based on feedback from the environment is a crucial means by which
organisms learn and develop optimal behavioral strategies. Norepinephrine (NE) release …