Molecular docking as a tool for the discovery of molecular targets of nutraceuticals in diseases management

PC Agu, CA Afiukwa, OU Orji, EM Ezeh, IH Ofoke… - Scientific Reports, 2023 - nature.com
Molecular docking is a computational technique that predicts the binding affinity of ligands to
receptor proteins. Although it has potential uses in nutraceutical research, it has developed …

A comprehensive review of the protective effects of herbals against toxicity of Bisphenol-A

D Katiyar, R Saxena, A Kumar, P Bansal… - Toxin …, 2024 - Taylor & Francis
Bisphenol-A (BPA) is a synthetically manufactured phenolic substance that is very widely
employed in producing polycarbonate polymers and epoxy resins which further can be …

Induction of reproductive injury by bisphenol A and the protective effects of cyanidin-3-O-glucoside and protocatechuic acid in rats

R Liu, B Liu, L Tian, X Wu, X Li, D Cai, X Jiang… - Science of the Total …, 2023 - Elsevier
Bisphenol A (BPA) has attracted growing attention as a well-known environmental pollutant
due to its high risk of male reproductive toxicity. In this study, transcriptomics profiling …

Cucumeropsis mannii seed oil protects against Bisphenol A‐induced testicular mitochondrial damages

PM Aja, HA Ogwoni, PC Agu, EU Ekpono… - Food Science & …, 2023 - Wiley Online Library
There has been increasing search for the ameliorative properties of seed oils against
toxicants. bisphenol A acts as an estrogenic endocrine‐disrupting chemical capable of …

Procyanidine alleviates bisphenol A-induced apoptosis in TM3 cells via the Nrf2 signaling pathway

F Pan, W Yang, T Zhao, K Liu, S Zhao… - Food and Chemical …, 2024 - Elsevier
Contaminated foods are a major source of bisphenol A (BPA) and are widely used in food
packaging. Prolonged exposure to BPA can cause reproductive dysfunction in humans …

Cucumeropsis mannii seed oil (CMSO) restores testicular mitochondrial dysfunctions by modulating the activities of dysregulated testicular mitochondrial enzymes in …

HA Ogwoni, PM Aja, ED Eze, PC Agu… - Food Science & …, 2024 - Wiley Online Library
Bisphenol A, a traditional endocrine disruptor, has been implicated in male infertility. This
study investigated the effect of Cucumeropsis mannii seed oil (CMSO) on bisphenol A (BPA) …

[HTML][HTML] Protective effect of Ficus capensis lyophilized extract against carboplatin-induced liver injury via inhibition of oxidative stress and inflammation in rats

JA Nwadibia, IV Fasogbon, AM Musyoka, EU Ekpono… - Toxicology Reports, 2024 - Elsevier
Patients who are receiving carboplatin therapy for cancer often experience toxic side effects.
This study examined the effects of lyophilized aqueous leaf extracts of F. capensis (LALEFC) …

Cucurbita Pepo L. Seed Oil Modulates Dyslipidemia and Neuronal Dysfunction in Tramadol-Induced Toxicity in Wistar Albino Rats

EU Ekpono, PM Aja, UA Ibiam, PC Agu… - Dose …, 2024 - journals.sagepub.com
Objective: The modulating effects of Cucurbita pepo seed oil (CPSO) on dyslipidemia and
neuronal dysfunction in tramadol toxicity were studied. Methods: Fifty-six albino rats were …

[HTML][HTML] Cucumeropsis mannii seed oil mitigates bisphenol-A-induced sperm and hormonal damages in F1-generation of F0-exposed male rats: An in-vivo and in …

PC Agu, HA Ogwoni, PN Suravajhala, R Suravajhala… - Results in …, 2024 - Elsevier
Exposure to endocrine-disrupting chemicals such as bisphenol A (BPA) has been linked to
the sharp drop in male fertility observed worldwide. This study evaluates the protective …

[HTML][HTML] Renoprotective effects of Cucumeropsis mannii seed oil on cisplatin-induced nephrotoxicity in Wistar rats

BA Ale, PM Aja, IJ Okoro, FE Nwite, PC Agu, ED Eze… - Phytomedicine Plus, 2024 - Elsevier
Background The growing prevalence of cancer and the concomitant rise in chemotherapy
use have led to an increased incidence of kidney-related diseases, including nephrotoxicity …