SARS-CoV-2 pathogenesis

MM Lamers, BL Haagmans - Nature reviews microbiology, 2022 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop …

Hypertension, thrombosis, kidney failure, and diabetes: is COVID-19 an endothelial disease? A comprehensive evaluation of clinical and basic evidence

C Sardu, J Gambardella, MB Morelli, X Wang… - Journal of clinical …, 2020 - mdpi.com
The symptoms most commonly reported by patients affected by coronavirus disease (COVID-
19) include cough, fever, and shortness of breath. However, other major events usually …

Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19

R Alon, M Sportiello, S Kozlovski, A Kumar… - Nature Reviews …, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
coronavirus disease 2019 (COVID-19). Understanding of the fundamental processes …

The role of neutrophil extracellular traps in acute lung injury

D Scozzi, F Liao, AS Krupnick, D Kreisel… - Frontiers in …, 2022 - frontiersin.org
Acute lung injury (ALI) is a heterogeneous inflammatory condition associated with high
morbidity and mortality. Neutrophils play a key role in the development of different forms of …

Endothelial damage in acute respiratory distress syndrome

AG Vassiliou, A Kotanidou, I Dimopoulou… - International journal of …, 2020 - mdpi.com
The pulmonary endothelium is a metabolically active continuous monolayer of squamous
endothelial cells that internally lines blood vessels and mediates key processes involved in …

[HTML][HTML] From ARDS to pulmonary fibrosis: the next phase of the COVID-19 pandemic?

JE Michalski, JS Kurche, DA Schwartz - Translational Research, 2022 - Elsevier
While the coronavirus disease 19 (COVID-19) pandemic has transformed the medical and
scientific communites since it was first reported in late 2019, we are only beginning to …

[HTML][HTML] Intestinal barrier damage, systemic inflammatory response syndrome, and acute lung injury: A troublesome trio for acute pancreatitis

P Ge, Y Luo, CS Okoye, H Chen, J Liu, G Zhang… - Biomedicine & …, 2020 - Elsevier
Severe acute pancreatitis (SAP), a serious inflammatory disease of the pancreas, can easily
lead to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction …

SARS-CoV-2 mediated endothelial dysfunction: the potential role of chronic oxidative stress

R Chang, A Mamun, A Dominic, NT Le - Frontiers in physiology, 2021 - frontiersin.org
Endothelial cells have emerged as key players in SARS-CoV-2 infection and COVID-19
inflammatory pathologies. Dysfunctional endothelial cells can promote chronic inflammation …

Alveolar epithelial cell type II as main target of SARS-CoV-2 virus and COVID-19 development via NF-Kb pathway deregulation: A physio-pathological theory

M Carcaterra, C Caruso - Medical hypotheses, 2021 - Elsevier
Abstract The Corona Virus Disease (COVID-19) pandemic caused by Severe Acute
Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) requires a rapid solution and global …

Mechanisms governing anaphylaxis: inflammatory cells, mediators, endothelial gap junctions and beyond

SMT Nguyen, CP Rupprecht, A Haque… - International journal of …, 2021 - mdpi.com
Anaphylaxis is a severe, acute, life-threatening multisystem allergic reaction resulting from
the release of a plethora of mediators from mast cells culminating in serious respiratory …