With the detailed description and analysis of several inhibitory receptor systems on lymphoid
and myeloid cells, a central paradigm has emerged in which the pairing of activation and …

Receptors for immunoglobulin Fc regions play multiple critical roles in the immune system,
mediating functions as diverse as phagocytosis, triggering degranulation of basophils and …

SHIP is a 145-kD SH 2-containing i nositol-5-p hosphatase widely expressed in hemopoietic
cells. It was first identified as a tyrosine phosphoprotein associated with Shc in response to …

The critical role for the SH2 domain-containing SHP-1 tyrosine phosphatase in regulating
haemopoietic cell behaviour was initially revealed by data linking SHP-1 deficiency to the …

Immune cells are activated as a result of productive interactions between ligands and
various receptors known as immunoreceptors. These receptors function by recruiting …

Publisher Summary Cell activation triggered by immune receptors—such as the B cell, T
cell, or Fc receptor (BCR, TCR, or FcR)—displays the capacity to undergo fine modulation to …

Ship is an Src homology 2 domain containing inositol polyphosphate 5-phosphatase which
has been implicated as an important signaling molecule in hematopoietic cells. In B cells …

Background: To elucidate the role of the Src family kinase Lyn in B cell receptor (BCR)
signaling, we and others previously generated lyn−/− mice and analyzed their B cell …

Paired immunoglobulin-like receptor B (PIR-B)(p91) molecule has been proposed to
function as an inhibitory receptor in B cells and myeloid lineage cells. We demonstrate here …

Coligation of paired immunoglobulin-like receptor B (PIR-B) with B cell antigen receptor
(BCR) blocks antigen-induced B cell activation. This inhibition is mediated in part by …