The concentration of sodium ions (Na+) is raised in solid tumours and can be measured at
the cellular, tissue and patient levels. At the cellular level, the Na+ gradient across the …

The TMC1 channel was identified as a protein essential for hearing in mouse and human,
and recognized as one of a family of eight such proteins in mammals. The TMC family is part …

Sodium (Na+) ions are known to regulate many signaling pathways involved in both
physiological and pathological conditions. In particular, alterations in intracellular …

Nanodiamonds (NDs) possess many excellent physical and chemical properties that make
them attractive materials for applications in biomedicine. In this paper, the adsorption and …

Human glioblastoma (GBM) cells are notorious for their resistance to apoptosis-inducing
therapeutics. We have identified lanatoside C as a sensitizer of GBM cells to tumor necrosis …

The epithelial Na+ channel (ENaC) and acid-sensitive ion channel (ASIC) branches of the
ENaC/degenerin superfamily of cation channels have drawn increasing attention as …

Glioblastoma is a rapidly progressive and extremely fatal form of brain tumor with poor
prognosis. It is the most common type of primary brain tumor. Even with the most aggressive …

Herpesviruses are prevalent throughout the animal kingdom, and they have coexisted and
coevolved along with their host species for millions of years. Herpesviruses carry a large …

Since its emergence onto the gene therapy scene nearly 25 years ago, the replication-
defective Herpes Simplex Virus Type-1 (HSV-1) amplicon has gained significance as a …

Amiloride is a small molecule diuretic, which has been used to dissect sodium transport
pathways in many different systems. This drug is known to interact with the epithelial sodium …