Natural epidithiodiketopiperazine alkaloids as potential anticancer agents: Recent mechanisms of action, structural modification, and synthetic strategies
L Wang, Q Jiang, S Chen, S Wang, J Lu, X Gao… - Bioorganic …, 2023 - Elsevier
Cancer has become a grave health crisis that threatens the lives of millions of people
worldwide. Because of the drawbacks of the available anticancer drugs, the development of …
worldwide. Because of the drawbacks of the available anticancer drugs, the development of …
Concise Synthesis of 2, 5-Diketopiperazines via Catalytic Hydroxy-Directed Peptide Bond Formations
M Koshizuka, K Shinoda, K Makino… - The Journal of Organic …, 2023 - ACS Publications
2, 5-Diketopiperazines (DKPs) with hydroxymethyl functional groups are essential structures
found in many bioactive molecules and functional materials. We have established a simple …
found in many bioactive molecules and functional materials. We have established a simple …
Synthetic Studies toward Dimeric Indole Alkaloids Based on Convergent Synthetic Strategy
H Ueda - Chemical and Pharmaceutical Bulletin, 2020 - jstage.jst.go.jp
The total syntheses of dimeric indole alkaloids, haplophytine, and T988s are described.
These dimeric compounds comprising two structurally different indole units are ubiquitous in …
These dimeric compounds comprising two structurally different indole units are ubiquitous in …
Concise approach to the syntheses of (±)-gliocladin C and related diketopiperazine alkaloids
TR Hodges, NM Benjamin, SF Martin - Tetrahedron, 2018 - Elsevier
A unique approach to the diketopiperazine indole alkaloid (±)-gliocladin C was developed
and applied to formal syntheses of the related alkaloids (±)-gliocladine C and (±)-T988C …
and applied to formal syntheses of the related alkaloids (±)-gliocladine C and (±)-T988C …
A Transannular Rearrangement Reaction of a Pyrroloindoline Diketopiperazine
Oxaline, glandicoline, and meleagrin contain a unique triazaspirocyclic structure. Attracted
by their biological activities, we attempted a novel strategy, mimicking a proposed …
by their biological activities, we attempted a novel strategy, mimicking a proposed …