Effects of arachidonic acid metabolites on cardiovascular health and disease
Arachidonic acid (AA) is an essential fatty acid that is released by phospholipids in cell
membranes and metabolized by cyclooxygenase (COX), cytochrome P450 (CYP) enzymes …
membranes and metabolized by cyclooxygenase (COX), cytochrome P450 (CYP) enzymes …
Linoleic acid and the pathogenesis of obesity
The modern Western diet has been consumed in developed English speaking countries for
the last 50 years, and is now gradually being adopted in Eastern and developing countries …
the last 50 years, and is now gradually being adopted in Eastern and developing countries …
20-HETE in the regulation of vascular and cardiac function
P Rocic, ML Schwartzman - Pharmacology & therapeutics, 2018 - Elsevier
HETE, the ω-hydroxylation product of arachidonic acid catalyzed by enzymes of the
cytochrome P450 (CYP) 4A and 4F gene families, is a bioactive lipid mediator with potent …
cytochrome P450 (CYP) 4A and 4F gene families, is a bioactive lipid mediator with potent …
The expansive role of oxylipins on platelet biology
J Yeung, M Hawley, M Holinstat - Journal of molecular medicine, 2017 - Springer
In mammals, three major oxygenases, cyclooxygenases (COXs), lipoxygenases (LOXs), and
cytochrome P450 (CYP450), generate an assortment of unique lipid mediators (oxylipins) …
cytochrome P450 (CYP450), generate an assortment of unique lipid mediators (oxylipins) …
Adult stem cells and diseases of aging
LB Boyette, RS Tuan - Journal of clinical medicine, 2014 - mdpi.com
Preservation of adult stem cells pools is critical for maintaining tissue homeostasis into old
age. Exhaustion of adult stem cell pools as a result of deranged metabolic signaling …
age. Exhaustion of adult stem cell pools as a result of deranged metabolic signaling …
The role of 20-HETE in cardiovascular diseases and its risk factors
M Waldman, SJ Peterson, M Arad… - Prostaglandins & other …, 2016 - Elsevier
Arachidonic acid (AA) is metabolized in mammals by enzymes of the CYP4A and 4F families
to 20-hydroxyeicosatetraeonic acid (20-HETE) which plays an important role in the …
to 20-hydroxyeicosatetraeonic acid (20-HETE) which plays an important role in the …
Epoxyeicosatrienoic acids regulate adipocyte differentiation of mouse 3T3 cells, via PGC-1α activation, which is required for HO-1 expression and increased …
Epoxyeicosatrienoic acid (EET) contributes to browning of white adipose stem cells to
ameliorate obesity/diabetes and insulin resistance. In the current study, we show that EET …
ameliorate obesity/diabetes and insulin resistance. In the current study, we show that EET …
Cytochrome p450 enzymes in the bioactivation of polyunsaturated Fatty acids and their role in cardiovascular disease
C Westphal, A Konkel, WH Schunck - Monooxygenase, Peroxidase and …, 2015 - Springer
Various members of the cytochrome P450 (CYP) superfamily have the capacity of
metabolizing omega-6 and omega-3 polyunsaturated fatty acids (n-6 and n-3 PUFAs). In …
metabolizing omega-6 and omega-3 polyunsaturated fatty acids (n-6 and n-3 PUFAs). In …
CYP2J2 molecular recognition: a new axis for therapeutic design
Cytochrome P450 (CYP) epoxygenases are a special subset of heme-containing CYP
enzymes capable of performing the epoxidation of polyunsaturated fatty acids (PUFA) and …
enzymes capable of performing the epoxidation of polyunsaturated fatty acids (PUFA) and …
20-HETE interferes with insulin signaling and contributes to obesity-driven insulin resistance
A Gilani, K Agostinucci, S Hossain, JV Pascale… - Prostaglandins & other …, 2021 - Elsevier
HETE, a metabolite of arachidonic acid produced by Cytochrome P450 (CYP) 4A/4 F, has
been implicated in the development of obesity-associated complications such as diabetes …
been implicated in the development of obesity-associated complications such as diabetes …