Lipid peroxidation-derived aldehydes, 4-hydroxynonenal and malondialdehyde in aging-related disorders

G Barrera, S Pizzimenti, M Daga, C Dianzani, A Arcaro… - Antioxidants, 2018 - mdpi.com
Among the various mechanisms involved in aging, it was proposed long ago that a
prominent role is played by oxidative stress. A major way by which the latter can provoke …

Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review

J Riegger, A Schoppa, L Ruths… - Cellular & molecular …, 2023 - Springer
During aging and after traumatic injuries, cartilage and bone cells are exposed to various
pathophysiologic mediators, including reactive oxygen species (ROS), damage-associated …

Oxidative stress‐related biomarkers in postmenopausal osteoporosis: a systematic review and meta‐analyses

Q Zhou, L Zhu, D Zhang, N Li, Q Li, P Dai… - Disease …, 2016 - Wiley Online Library
Numerous studies suggested that oxidative stress (OS) played a central role in the onset
and development of postmenopausal osteoporosis (PO); however, conflicting results were …

Osteoporosis and Alzheimer´ s disease (or Alzheimer´ s disease and Osteoporosis)

NE Wanionok, GR Morel, JM Fernández - Ageing Research Reviews, 2024 - Elsevier
Alzheimer's disease (AD) and osteoporosis are two diseases that mainly affect elderly
people, with increases in the occurrence of cases due to a longer life expectancy. Several …

Aberrant MFN2 transcription facilitates homocysteine‐induced VSMCs proliferation via the increased binding of c‐Myc to DNMT1 in atherosclerosis

L Xu, H Hao, Y Hao, G Wei, G Li, P Ma… - Journal of Cellular …, 2019 - Wiley Online Library
It is well‐established that homocysteine (Hcy) is an independent risk factor for
atherosclerosis. Hcy can promote vascular smooth muscle cell (VSMC) proliferation, it plays …

Association between dietary folate intake and bone mineral density in a diverse population: a cross-sectional study

Z Zheng, H Luo, W Xu, Q Xue - Journal of Orthopaedic Surgery and …, 2023 - Springer
Background Osteoporosis is a major public health problem, yet the association between
dietary folate intake and bone health has been rarely studied. This study aimed to …

Associations of global biomarkers of oxidative stress with osteoporosis, bone microstructure and bone turnover: Evidence from human and animal studies

X Shen, M Zhang, H Cai, WD Leslie, LM Lix, D Jiang… - Bone, 2024 - Elsevier
Purpose Human evidence on the association between oxidative stress and osteoporosis is
inconsistent. Fluorescent Oxidation Products (FlOPs) are global biomarkers of oxidative …

Folic acid supplementation prevents high body fat-induced bone loss through TGR5 signaling pathways

Y Zhang, J Wei, X Feng, Q Lin, J Deng, Y Yuan, M Li… - Food & Function, 2024 - pubs.rsc.org
Osteoporosis caused by bone loss is one of the serious global public health problems. Folic
acid is a B vitamin with multiple physiological functions such as lipid regulation and …

Systemic oxidative stress in old rats is associated with both osteoporosis and cognitive impairment

ML Torres, NE Wanionok, AD McCarthy… - Experimental …, 2021 - Elsevier
Aging is associated both with an increase in memory loss and with comorbidities such as
Osteoporosis, which could be causatively linked. In the present study, a deleterious effect on …

Folate ameliorates homocysteine-induced osteoblast dysfunction by reducing endoplasmic reticulum stress-activated PERK/ATF-4/CHOP pathway in MC3T3-E1 cells

S Su, D Zhang, J Liu, H Zhao, X Tang, H Che… - Journal of Bone and …, 2022 - Springer
Abstract Introduction Homocysteine (Hcy) is considered a newly identified risk factor for
osteoporosis. Nevertheless, the underlying mechanism of folate (FA), a key factor in the …