Lassa fever—the road ahead
RF Garry - Nature Reviews Microbiology, 2023 - nature.com
Lassa virus (LASV) is endemic in the rodent populations of Sierra Leone, Nigeria and other
countries in West Africa. Spillover to humans occurs frequently and results in Lassa fever, a …
countries in West Africa. Spillover to humans occurs frequently and results in Lassa fever, a …
Baseline mapping of Lassa fever virology, epidemiology and vaccine research and development
HJ Hallam, S Hallam, SE Rodriguez, ADT Barrett… - NPJ vaccines, 2018 - nature.com
Lassa fever (LF) is a zoonotic disease associated with acute and potentially fatal
hemorrhagic illness caused by the Lassa virus (LASV), a member of the family Arenaviridae …
hemorrhagic illness caused by the Lassa virus (LASV), a member of the family Arenaviridae …
Lassa virus glycoprotein nanoparticles elicit neutralizing antibody responses and protection
PJM Brouwer, A Antanasijevic, AJ Ronk… - Cell Host & Microbe, 2022 - cell.com
The Lassa virus is endemic in parts of West Africa, and it causes hemorrhagic fever with high
mortality. The development of a recombinant protein vaccine has been hampered by the …
mortality. The development of a recombinant protein vaccine has been hampered by the …
Structural basis for antibody-mediated neutralization of Lassa virus
KM Hastie, MA Zandonatti, LM Kleinfelter, ML Heinrich… - Science, 2017 - science.org
The arenavirus Lassa causes severe hemorrhagic fever and a significant disease burden in
West Africa every year. The glycoprotein, GPC, is the sole antigen expressed on the viral …
West Africa every year. The glycoprotein, GPC, is the sole antigen expressed on the viral …
A cocktail of protective antibodies subverts the dense glycan shield of Lassa virus
H Li, T Buck, M Zandonatti, J Yin… - Science translational …, 2022 - science.org
Developing potent therapeutics and effective vaccines are the ultimate goals in controlling
infectious diseases. Lassa virus (LASV), the causative pathogen of Lassa fever (LF), infects …
infectious diseases. Lassa virus (LASV), the causative pathogen of Lassa fever (LF), infects …
Non-neutralizing antibodies elicited by recombinant Lassa–Rabies vaccine are critical for protection against Lassa fever
T Abreu-Mota, KR Hagen, K Cooper… - Nature …, 2018 - nature.com
Lassa fever (LF), caused by Lassa virus (LASV), is a viral hemorrhagic fever for which no
approved vaccine or potent antiviral treatment is available. LF is a WHO priority disease and …
approved vaccine or potent antiviral treatment is available. LF is a WHO priority disease and …
Delayed low-dose oral administration of 4′-fluorouridine inhibits pathogenic arenaviruses in animal models of lethal disease
SR Welch, JR Spengler, JB Westover… - Science Translational …, 2024 - science.org
Development of broad-spectrum antiviral therapies is critical for outbreak and pandemic
preparedness against emerging and reemerging viruses. Viruses inducing hemorrhagic …
preparedness against emerging and reemerging viruses. Viruses inducing hemorrhagic …
Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever
CE Mire, RW Cross, JB Geisbert, V Borisevich… - Nature medicine, 2017 - nature.com
There are no approved treatments for Lassa fever, which is endemic to the same regions of
West Africa that were recently devastated by Ebola. Here we show that a combination of …
West Africa that were recently devastated by Ebola. Here we show that a combination of …
Pathogenicity and virulence mechanisms of Lassa virus and its animal modeling, diagnostic, prophylactic, and therapeutic developments
HL Murphy, H Ly - Virulence, 2021 - Taylor & Francis
Lassa fever (LF) is a deadly viral hemorrhagic disease that is endemic to West Africa. The
causative agent of LF is Lassa virus (LASV), which causes approximately 300,000 infections …
causative agent of LF is Lassa virus (LASV), which causes approximately 300,000 infections …
Crimean-Congo hemorrhagic fever virus: current advances and future prospects of antiviral strategies
S Dai, F Deng, H Wang, Y Ning - Viruses, 2021 - mdpi.com
Crimean-Congo hemorrhagic fever virus (CCHFV) is a widespread, tick-borne pathogen that
causes Crimean-Congo hemorrhagic fever (CCHF) with high morbidity and mortality …
causes Crimean-Congo hemorrhagic fever (CCHF) with high morbidity and mortality …