[HTML][HTML] Matrix metalloproteinases in liver injury, repair and fibrosis
The liver is a large highly vascularized organ with a central function in metabolic
homeostasis, detoxification, and immunity. Due to its roles, the liver is frequently exposed to …
homeostasis, detoxification, and immunity. Due to its roles, the liver is frequently exposed to …
[HTML][HTML] Matrix metalloproteinases and liver fibrosis (translational aspects)
E Roeb - Matrix Biology, 2018 - Elsevier
Liver fibrosis, a reversible wound-healing response to chronic cellular injury, reflects a
balance between liver repair and progressive substitution of the liver parenchyma by scar …
balance between liver repair and progressive substitution of the liver parenchyma by scar …
[HTML][HTML] Matrix metalloproteinases as potential biomarkers and therapeutic targets in liver diseases
E Geervliet, R Bansal - Cells, 2020 - mdpi.com
Chronic liver diseases, characterized by an excessive accumulation of extracellular matrix
(ECM) resulting in scar tissue formation, are a growing health problem causing increasing …
(ECM) resulting in scar tissue formation, are a growing health problem causing increasing …
Involvement of matrix metalloproteinases (MMPs) and inflammasome pathway in molecular mechanisms of fibrosis
Fibrosis is a basic connective tissue lesion defined by the increase in the fibrillar
extracellular matrix (ECM) components in tissue or organ. Matrix metalloproteinases (MMPs) …
extracellular matrix (ECM) components in tissue or organ. Matrix metalloproteinases (MMPs) …
Matrix metalloproteinase functions in hepatic injury and fibrosis
M Roderfeld - Matrix Biology, 2018 - Elsevier
Liver fibrosis is the most common final outcome for chronic liver diseases. The complex
pathogenesis includes hepatic parenchymal damage as a result of a persistent noxe …
pathogenesis includes hepatic parenchymal damage as a result of a persistent noxe …
Continuous production of highly functional vascularized hepatobiliary organoids from human pluripotent stem cells using a scalable microfluidic platform
S Abbasalizadeh, S Babaee… - Advanced Functional …, 2023 - Wiley Online Library
Abstract “Organoid medicine” has rapidly progressed over the past decade as a new class of
therapeutics with high functionality and complexity for addressing unmet medical needs …
therapeutics with high functionality and complexity for addressing unmet medical needs …
Anthocyanins isolated from blueberry ameliorates CCl4 induced liver fibrosis by modulation of oxidative stress, inflammation and stellate cell activation in mice
J Sun, Y Wu, C Long, P He, J Gu, L Yang… - Food and Chemical …, 2018 - Elsevier
To study the mechanism of anthocyanins from blueberry on mice model of hepatic fibrosis.
We observed that the levels of serum ALT and AST of 100 mg* kg-1* d-1, 200 mg* kg-1* d-1 …
We observed that the levels of serum ALT and AST of 100 mg* kg-1* d-1, 200 mg* kg-1* d-1 …
ACE2: from protection of liver disease to propagation of COVID-19
FJ Warner, H Rajapaksha, N Shackel… - Clinical …, 2020 - portlandpress.com
Twenty years ago, the discovery of angiotensin-converting enzyme 2 (ACE2) was an
important breakthrough dramatically enhancing our understanding of the renin–angiotensin …
important breakthrough dramatically enhancing our understanding of the renin–angiotensin …
[HTML][HTML] Atorvastatin for patients with cirrhosis. A randomized, placebo-controlled trial
TM Kronborg, R Schierwagen, K Trošt… - Hepatology …, 2023 - journals.lww.com
Background: Patients with cirrhosis and portal hypertension face a high risk of
complications. Besides their anti-inflammatory and antifibrotic effects, statins may reduce …
complications. Besides their anti-inflammatory and antifibrotic effects, statins may reduce …
[HTML][HTML] Extracellular vesicles: a new frontier in biomarker discovery for non-alcoholic fatty liver disease
LA Ban, NA Shackel, SV McLennan - International journal of molecular …, 2016 - mdpi.com
In recent years, the global burden of obesity and diabetes has seen a parallel rise in other
metabolic complications, such as non-alcoholic fatty liver disease (NAFLD). This condition …
metabolic complications, such as non-alcoholic fatty liver disease (NAFLD). This condition …