The liver is a large highly vascularized organ with a central function in metabolic
homeostasis, detoxification, and immunity. Due to its roles, the liver is frequently exposed to …

Liver fibrosis, a reversible wound-healing response to chronic cellular injury, reflects a
balance between liver repair and progressive substitution of the liver parenchyma by scar …

Chronic liver diseases, characterized by an excessive accumulation of extracellular matrix
(ECM) resulting in scar tissue formation, are a growing health problem causing increasing …

Fibrosis is a basic connective tissue lesion defined by the increase in the fibrillar
extracellular matrix (ECM) components in tissue or organ. Matrix metalloproteinases (MMPs) …

Liver fibrosis is the most common final outcome for chronic liver diseases. The complex
pathogenesis includes hepatic parenchymal damage as a result of a persistent noxe …

Abstract “Organoid medicine” has rapidly progressed over the past decade as a new class of
therapeutics with high functionality and complexity for addressing unmet medical needs …

To study the mechanism of anthocyanins from blueberry on mice model of hepatic fibrosis.
We observed that the levels of serum ALT and AST of 100 mg* kg-1* d-1, 200 mg* kg-1* d-1 …

Twenty years ago, the discovery of angiotensin-converting enzyme 2 (ACE2) was an
important breakthrough dramatically enhancing our understanding of the renin–angiotensin …

Background: Patients with cirrhosis and portal hypertension face a high risk of
complications. Besides their anti-inflammatory and antifibrotic effects, statins may reduce …

In recent years, the global burden of obesity and diabetes has seen a parallel rise in other
metabolic complications, such as non-alcoholic fatty liver disease (NAFLD). This condition …