Copper-Promoted Functionalization of Organic Molecules: from Biologically Relevant Cu/O2 Model Systems to Organometallic Transformations

R Trammell, K Rajabimoghadam… - Chemical …, 2019 - ACS Publications
Copper is one of the most abundant and less toxic transition metals. Nature takes advantage
of the bioavailability and rich redox chemistry of Cu to carry out oxygenase and oxidase …

Palladium (II)-catalyzed alkene functionalization via nucleopalladation: stereochemical pathways and enantioselective catalytic applications

RI McDonald, G Liu, SS Stahl - Chemical reviews, 2011 - ACS Publications
The development of catalytic reactions of alkenes transformed the chemical industry in the
mid-20th century. Representative reactions included hydrogenation, oxidation …

Catalytic enantioselective functionalization of unactivated terminal alkenes

JR Coombs, JP Morken - Angewandte Chemie International …, 2016 - Wiley Online Library
Terminal alkenes are readily available functional groups which appear in α‐olefins
produced by the chemical industry, and they appear in the products of many contemporary …

The mechanism of the Wacker reaction: a tale of two hydroxypalladations

JA Keith, PM Henry - Angewandte Chemie International Edition, 2009 - Wiley Online Library
We present a concise review on the most pertinent investigations that illuminate the
complicated and elusive mechanism for the Wacker process, homogeneous olefin oxidation …

Challenging 50 years of established views on Ugi reaction: a theoretical approach

N Chéron, R Ramozzi, LE Kaïm… - The Journal of …, 2012 - ACS Publications
The Ugi reaction is one of the most famous multicomponent couplings, and its efficiency is
still explained by the original mechanism suggested by Ugi in the 60s. This article aims to …

Sustainable Wacker‐Type Oxidations

P Rajeshwaran, J Trouvé, K Youssef… - Angewandte Chemie …, 2022 - Wiley Online Library
The Wacker reaction is the oxidation of olefins to ketones and typically requires expensive
and scarce palladium catalysts in the presence of an additional copper co‐catalyst under …

Catalyst Complexity in a Highly Active and Selective Wacker-Type Markovnikov Oxidation of Olefins with a Bioinspired Iron Complex

J Trouvé, K Youssef, S Kasemthaveechok… - ACS …, 2023 - ACS Publications
Palladium-catalyzed Wacker-type reactions occupy a central place in organic synthesis with
important implications in industry. Pursuing more benign protocols by replacing palladium …

Wacker-type oxidation of alkynes into 1, 2-diketones using molecular oxygen

W Ren, Y Xia, SJ Ji, Y Zhang, X Wan, J Zhao - Organic Letters, 2009 - ACS Publications
An intriguing new Wacker-type oxidation of alkynes catalyzed by PdBr2 and CuBr2 is
described, which opens an efficient access to 1, 2-diketones using molecular oxygen. Under …

Stabilizing Au (III) in supported-ionic-liquid-phase (SILP) catalyst using CuCl2 via a redox mechanism

J Zhao, Y Yu, X Xu, S Di, B Wang, H Xu, J Ni… - Applied Catalysis B …, 2017 - Elsevier
High-valent Au (III) complexes have attracted much attention as catalysts in many reactions.
Nevertheless Au (III) catalysts suffer from instability of the oxidized metal complexes during …

Neurotrophic natural products: chemistry and biology

J Xu, MH Lacoske… - Angewandte Chemie …, 2014 - Wiley Online Library
Neurodegenerative diseases and spinal cord injury affect approximately 50 million people
worldwide, bringing the total healthcare cost to over 600 billion dollars per year. Nervous …