Acetylcholine (ACh) neurotransmitter of the cholinergic system in the brain is involved in
learning, memory, stress responses, and cognitive functioning. It is hydrolyzed into choline …

Alzheimer's disease (AD) is a well known neurodegenerative disorder alarming millions of
people worldwide and the subsequent epidemiological statistics highlights the implication of …

The study of coumarin dates back to 1820 when coumarin was first extracted from tonka
bean by Vogel. Compounds containing coumarin backbone are a very important group of …

New 2-oxo-chromene-7-oxymethylene acetohydrazide derivatives 4a–d were designed and
synthesized with a variety of bioactive chemical fragments. The newly synthesized …

Hybridization is emerged as a promising strategy in the discovery of new drugs, especially
these with complimentary activities and multiple pharmacological targets that are the …

Alzheimer's disease (AD) is a major progressive and perplexing cortical degenerative
disease of the brain in the elderly. It contributes to a significant socioeconomic burden on …

Abstract A number of N-(2-(1H-indol-3-yl) ethyl)-2-oxo-2H-chromene-3-carboxamides were
synthesized and tested against AChE and BuChE. The in vitro assessment of the …

Alzheimer's disease is a most prevalent form of dementia all around the globe and currently
poses a significant challenge to the healthcare system. Currently available drugs only slow …

Heavy metals such as Iron, Copper, and Zinc are micro-essential trace metal and involve
animportant biological role, but it quickly turns toxic at exceeding the permissible limit …

A new set of hybrid derivatives bearing pyrazole and coumarin scaffold 3a-f was synthesized
and confirmed by different spectroscopic techniques (1 H NMR, 13 C NMR, FT-IR) and mass …