Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene
silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be …

Epigenetic modifications are heritable changes in gene expression not encoded by the DNA
sequence. In the past decade, great strides have been made in characterizing epigenetic …

Breast cancers are highly heterogeneous but can be grouped into subtypes based on
several criteria, including level of expression of certain markers. Claudin-low breast cancer …

G9a is a mammalian histone methyltransferase that contributes to the epigenetic silencing of
tumor suppressor genes. Emerging evidence suggests that G9a is required to maintain the …

The pluripotency-determining gene Oct3/4 (also called Pou5f1) undergoes postimplantation
silencing in a process mediated by the histone methyltransferase G9a. Microarray analysis …

Methylation of DNA and lysine 9 of histone H3 (H3K9) are well‐conserved epigenetic marks
for transcriptional silencing. Although H3K9 methylation directs DNA methylation in …

By methylation of peptide arrays, we determined the specificity profile of the protein
methyltransferase G9a. We show that it mostly recognizes an Arg-Lys sequence and that its …

Summary Lysine 9 of histone 3 (H3K9) can be mono-, di-, or trimethylated, inducing distinct
effects on gene expression and chromatin compaction. H3K9 methylation can be mediated …

DNA methylation plays a crucial role in the regulation of gene expression and chromatin
organization within normal eukaryotic cells. In cancer, however, global patterns of DNA …

Mammalian euchromatic gene silencing results from the combined repressive effects of
histone and DNA methyltransferases. Little is known of the mechanism by which these …