Advances in the development of influenza virus vaccines

F Krammer, P Palese - Nature reviews Drug discovery, 2015 - nature.com
Influenza virus infections are a major public health concern and cause significant morbidity
and mortality worldwide. Current influenza virus vaccines are an effective countermeasure …

M2e-based universal influenza vaccines: a historical overview and new approaches to development

D Mezhenskaya, I Isakova-Sivak, L Rudenko - Journal of biomedical …, 2019 - Springer
The influenza A virus was isolated for the first time in 1931, and the first attempts to develop
a vaccine against the virus began soon afterwards. In addition to causing seasonal …

Universal influenza vaccines: Shifting to better vaccines

FB Scorza, V Tsvetnitsky, JJ Donnelly - Vaccine, 2016 - Elsevier
Influenza virus causes acute upper and lower respiratory infections and is the most likely,
among known pathogens, to cause a large epidemic in humans. Influenza virus mutates …

M2e-based universal influenza A vaccines

L Deng, KJ Cho, W Fiers, X Saelens - Vaccines, 2015 - mdpi.com
The successful isolation of a human influenza virus in 1933 was soon followed by the first
attempts to develop an influenza vaccine. Nowadays, vaccination is still the most effective …

Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments

M Schotsaert, M De Filette, W Fiers… - Expert review of …, 2009 - Taylor & Francis
Influenza vaccines used today are strain specific and need to be adapted every year to try
and match the antigenicity of the virus strains that are predicted to cause the next epidemic …

M2-based influenza vaccines: recent advances and clinical potential

A Kolpe, B Schepens, W Fiers… - Expert review of …, 2017 - Taylor & Francis
Introduction: Current influenza vaccines can prevent disease caused by influenza viruses
but require annual administration and almost yearly reformulation. An attractive alternative …

Virus-like particles containing multiple M2 extracellular domains confer improved cross-protection against various subtypes of influenza virus

MC Kim, JM Song, O Eunju, YM Kwon, YJ Lee… - Molecular Therapy, 2013 - cell.com
The extracellular domain of M2 (M2e), a small ion channel membrane protein, is well
conserved among different human influenza A virus strains. To improve the protective …

Heterosubtypic influenza protection elicited by double-layered polypeptide nanoparticles in mice

L Deng, TZ Chang, Y Wang, S Li… - Proceedings of the …, 2018 - National Acad Sciences
Influenza is a persistent threat to public health. Here we report that double-layered peptide
nanoparticles induced robust specific immunity and protected mice against heterosubtypic …

Conserved epitopes of influenza A virus inducing protective immunity and their prospects for universal vaccine development

Z Staneková, E Varečková - Virology journal, 2010 - Springer
Influenza A viruses belong to the best studied viruses, however no effective prevention
against influenza infection has been developed. The emerging of still new escape variants …

Engineered probiotic Escherichia coli elicits immediate and long-term protection against influenza A virus in mice

L Huang, W Tang, L He, M Li, X Lin, A Hu… - Nature …, 2024 - nature.com
Influenza virus infection remains a major global health problem and requires a universal
vaccine with broad protection against different subtypes as well as a rapid-response vaccine …