Metabolic acidosis occurs when a relative accumulation of plasma anions in excess of
cations reduces plasma pH. Replacement of sodium bicarbonate to patients with sodium …

An understanding of the pathophysiology of lactic acidosis is crucial in facilitating the optimal
care of critically ill patients. The relevant biochemistry of lactic acidosis is reviewed, and the …

Lactic acidosis, a clinical syndrome caused by the accumulation of lactic acid, is
characterized by lactate concentration in blood greater than 5 m M. Therapy usually consists …

Lactic acidosis is a metabolic derangement associated with a variety of pathologic states.
Since the most common etiology is circulatory shock, lactic acidosis serves as an important …

Lactic acidosis in diabetics on metformin therapy is rare but still associated with poor
prognosis. The authors report here five cases. Three, patients were initially with a …

We used 31 P spectroscopy to determine whether administration of a neutralizing dose of
bicarbonate in rabbits with lactic acidosis caused a paradoxical brain intracellular acidosis …

Systemic and focal cerebral acidosis is considered deleterious to cell metabolism and
neuronal recovery. We investigated the immediate effect of tris-(hyroxymethyl) …

Metabolic acid-base disturbances commonly and predictably complicate the course of many
intensive care unit patients and plague the intensivists, surgeons, and anesthesiologists …

Serum lactic acidosis is characterized by a pH< 7.25 and lactate> 5 mEq. A Altough sodium
bicarbonate (NaHCO 3) is standard treatment for this condition, clinical and experimental …

There are a range of therapeutic options available for the management of type 2 diabetes in
the elderly. Diet remains the mainstay of treatment although this must be realistic. If diet …