Recent advances in the pharmacological diversification of quinazoline/quinazolinone hybrids
Due to the pharmacological activities of quinazoline and quinazolinone scaffolds, it has
aroused great interest in medicinal chemists for the development of new drugs or drug …
aroused great interest in medicinal chemists for the development of new drugs or drug …
Concept of hybrid drugs and recent advancements in anticancer hybrids
Cancer is a complex disease, and its treatment is a big challenge, with variable efficacy of
conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in …
conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in …
Quinoline–imidazole/benzimidazole derivatives as dual-/multi-targeting hybrids inhibitors with anticancer and antimicrobial activity
Two new classes of hybrid quinoline–imidazole/benzimidazole derivatives (the hybrid QIBS
salts and QIBC cycloadducts) were designed and synthesized to evaluate their anticancer …
salts and QIBC cycloadducts) were designed and synthesized to evaluate their anticancer …
Design, Synthesis, Biological Evaluation, 2D-QSAR Modeling, and Molecular Docking Studies of Novel 1H-3-Indolyl Derivatives as Significant Antioxidants
Novel candidates of 3-(4-(thiophen-2-yl)-pyridin/pyran/pyrimidin/pyrazol-2-yl)-1 H-indole
derivatives (2–12) were designed by pairing the pyridine/pyrane/pyrimidine/pyrazole …
derivatives (2–12) were designed by pairing the pyridine/pyrane/pyrimidine/pyrazole …
[HTML][HTML] Ultrasound-assisted one-pot green synthesis of new N-substituted-5-arylidene-thiazolidine-2, 4-dione-isoxazoline derivatives using NaCl/Oxone/Na3PO4 in …
A rapid and green method for the synthesis of novel N-thiazolidine-2, 4-dione isoxazoline
derivatives 5 from N-allyl-5-arylidenethiazolidine-2, 4-diones 3 as dipolarophiles with …
derivatives 5 from N-allyl-5-arylidenethiazolidine-2, 4-diones 3 as dipolarophiles with …
Navigating the synthesis of quinoline hybrid molecules as promising anticancer agents
P Panda, S Chakroborty - ChemistrySelect, 2020 - Wiley Online Library
The emergence of drug resistance and low specificity with side effects are the significant
challenges in pharmaceutical sectors for control of cancer nowadays. Notwithstanding, this …
challenges in pharmaceutical sectors for control of cancer nowadays. Notwithstanding, this …
Design, synthesis and in vitro antiproliferative activity of new thiazolidinedione-1,3,4-oxadiazole hybrids as thymidylate synthase inhibitors
ZMM Alzhrani, MM Alam, T Neamatallah… - Journal of Enzyme …, 2020 - Taylor & Francis
Thymidylate synthase (TS) has been an attention-grabbing area of research for the
treatment of cancers due to their role in DNA biosynthesis. In the present study, we have …
treatment of cancers due to their role in DNA biosynthesis. In the present study, we have …
Synthetic and naturally occurring heterocyclic anticancer compounds with multiple biological targets
Cancer is a complex group of diseases initiated by abnormal cell division with the potential
of spreading to other parts of the body. The advancement in the discoveries of omics and bio …
of spreading to other parts of the body. The advancement in the discoveries of omics and bio …
Nitrogen-fused heterocycles: Empowering anticancer drug discovery
The worldwide impact of cancer is further compounded by the constraints of current
anticancer medications, which frequently exhibit a lack of selectivity, raise safety …
anticancer medications, which frequently exhibit a lack of selectivity, raise safety …
Hybrid molecules containing naphthoquinone and quinolinedione scaffolds as antineoplastic agents
I Mancini, J Vigna, D Sighel, A Defant - Molecules, 2022 - mdpi.com
In recent decades, molecular hybridization has proven to be an efficient tool for obtaining
new synthetic molecules to treat different diseases. Based on the core idea of covalently …
new synthetic molecules to treat different diseases. Based on the core idea of covalently …