Enzymatic assays to explore viral mRNA capping machinery

R Kasprzyk, J Jemielity - ChemBioChem, 2021 - Wiley Online Library
In eukaryotes, mRNA is modified by the addition of the 7‐methylguanosine (m7G) 5′ cap to
protect mRNA from premature degradation, thereby enhancing translation and enabling …

Synthesis, Intramolecular Cyclization, and Anti-inflammatory Activity of Substituted 2-[2-(4-R-Benzoyl) hydrazinylidene]-4-oxobutanoic Acids

DV Lipin, EI Denisova, DA Shipilovskikh… - Russian Journal of …, 2022 - Springer
The substrate scope of the procedure for the synthesis of 2-[2-(4-R-benzoyl)
hydrazinylidene]-4-oxobutanoic acids was expanded, and their intramolecular cyclization in …

Synthesis, Intramolecular Cyclization, and Analgesic Activity of Substituted 2-[2-(Furancarbonyl) hydrazinylydene]-4-oxobutanoic Acids

SN Igidov, AY Turyshev, RR Makhmudov… - Russian Journal of …, 2022 - Springer
A method was proposed for the synthesis of substituted 2-[2-(furan-2-carbonyl)
hydrazinylidene]-4-oxobutanoic acids by the reaction of 4-aryl-2, 4-dioxobut-2-enoic acids …

Synthesis, Intramolecular Cyclization, and Antinociceptive Activity of Substituted 2-[2-(4-Nitrobenzoyl) hydrazinylidene]-4-oxobut-2-enoic Acids

EI Denisova, DV Lipin, KY Parkhoma… - Russian Journal of …, 2021 - Springer
Abstract New substituted 2-[2-(4-nitrobenzoyl) hydrazinylidene]-4-oxobut-2-enoic acids have
been synthesized by condensation of 4-nitrobenzohydrazide with 4-aryl-2, 4-dioxobutanoic …

Synthesis, anti-inflammatory activity, and acute toxicity of the substituted 2-[2-(4-nitrobenzoyl) hydrazono]-4-oxobutanoates

DV Lipin, SK Metlyakova, DA Shipilovskikh… - Russian Chemical …, 2023 - Springer
Abstract The reaction of substituted 3-(4-nitrobenzoyl) hydrazonofuran-2 (3 H)-ones with
primary alcohols gave the corresponding 2-[2-(4-nitrobenzoyl) hydrazono]-4-oxobutanoates …

Synthesis and Antinociceptive Activity of Substituted 5-(Het)aryl-3-(4-methylbenzoyl)hydrazono-3H-furan-2-ones

DV Lipin, EI Denisova, IО Devyatkin… - Russian Journal of …, 2021 - Springer
The method was proposed for the synthesis of new substituted 5-(het) aryl-3-(4-
methylbenzoyl) hydrazono-3 H-furan-2-ones by intramolecular cyclization of 2-[2-(4 …

Synthesis and intramolecular cyclization of substituted 4-(Het) aryl-4-oxo-2-thienylaminobut-2-enoic acids containing nitrile group in the thiophene ring

IA Gorbunova, DA Shipilovskikh, AE Rubtsov… - Russian Journal of …, 2021 - Springer
A method for the synthesis of substituted 4-(het) aryl-4-oxo-2-thienylaminobut-2-enoic acids
containing a nitrile substituent in the thiophene ring was proposed. Intramolecular …

Decyclization of Substituted 2-[2-Oxofuran-3(2H)-ylidene)furan-2-carbohydrazides by the Action of Alcohols and Analgesic Activity of the Obtained Compounds

SN Igidov, AY Turyshev, RR Makhmudov… - Russian Journal of …, 2023 - Springer
A new series of substituted 4-oxo-2-[2-(furan-2-ylcarbonyl) hydrazinylidene] butanoic acids
and 2-[2-oxofuran-3 (2 H)-ylidene] furan-2-carbohydrazides was synthesized. A …

Ring Opening of Substituted 3-[2-(4-Nitrobenzoyl)hydrazinylidene]furan-2(3H)-ones with Primary Alcohols. Analgesic Activity and Acute Toxicity of the Products

DV Lipin, EI Denisova, DA Shipilovskikh… - Russian Journal of …, 2023 - Springer
Abstract Ring opening of 5-substituted 3-[2-(4-nitrobenzoyl) hydrazinylidene] furan-2 (3 H)-
ones by the action of alcohols afforded the corresponding 4-substituted 2-[2-(4-nitrobenzoyl) …

Synthesis, intramolecular cyclization, and antinociceptive activity of 4-(het) aryl-2-{[4-(4-chlorophenyl)-3-(ethoxycarbonyl) thiophen-2-yl] amino}-4-oxobut-2-enoic …

IA Gorbunova, IP Nikonov, RR Makhmudov… - Russian Chemical …, 2023 - Springer
Synthesis and intramolecular cyclization of the substituted 4-(het) aryl-2-{[4-(4-chlorophenyl)-
3-(ethoxycarbonyl) thiophen-2-yl] amino}-4-oxobut-2-enoic acids were studied. It was found …