Nonribosomal peptide synthetases (NRPSs) are involved in the biosynthesis of numerous
peptide and peptide-like natural products that have been exploited in medicine, agriculture …

Adenylate-forming enzymes represent one of the most important enzyme classes in biology,
responsible for the activation of carboxylate substrates for biosynthetic modifications. The …

Interrupted adenylation domains are enigmatic fusions, in which one enzyme is inserted into
another to form a highly unusual bifunctional enzyme. We present the first crystal structure of …

Nonribosomal peptides (NRPs) are known sources of therapeutics. Some nonribosomal
peptide synthetase assembly lines contain unique functional interrupted adenylation (A) …

Thaxtomins are a group of phytotoxic diketopiperazines produced by tens of plant
pathogenic Streptomyces strains and have received considerable attention as bioherbicide …

Nonribosomal peptides (NRPs) are biosynthesized by nonribosomal peptide synthetases
(NRPSs) and are widely distributed in both terrestrial and marine organisms. Many NRPs …

Nonribosomal peptide synthetases use tailoring domains to incorporate chemical diversity
into the final natural product. A structurally unique set of tailoring domains are found to be …

Nonribosomal peptide synthetases, consisted of multiple catalytic domains, are involved in
the biosynthesis of an important family of bioactive natural products in a coordinated …

Interrupted adenylation (A) domains contain auxiliary domains within their structure and are
a subject of growing interest in the field of nonribosomal peptide biosynthesis. They have …

MbtH‐like proteins (MLPs) are required for soluble expression and/or optimal activity of
some adenylation (A) domains of nonribosomal peptide synthetases. Because A domains …