Crossroads of antibiotic resistance and biosynthesis
TA Wencewicz - Journal of molecular biology, 2019 - Elsevier
The biosynthesis of antibiotics and self-protection mechanisms employed by antibiotic
producers are an integral part of the growing antibiotic resistance threat. The origins of …
producers are an integral part of the growing antibiotic resistance threat. The origins of …
Conformational dynamics and enzyme evolution
D Petrović, VA Risso, SCL Kamerlin… - Journal of the …, 2018 - royalsocietypublishing.org
Enzymes are dynamic entities, and their dynamic properties are clearly linked to their
biological function. It follows that dynamics ought to play an essential role in enzyme …
biological function. It follows that dynamics ought to play an essential role in enzyme …
Assessing the performance of the MM/PBSA and MM/GBSA methods. 6. Capability to predict protein–protein binding free energies and re-rank binding poses …
Understanding protein–protein interactions (PPIs) is quite important to elucidate crucial
biological processes and even design compounds that interfere with PPIs with …
biological processes and even design compounds that interfere with PPIs with …
Updates to the integrated protein–protein interaction benchmarks: docking benchmark version 5 and affinity benchmark version 2
We present an updated and integrated version of our widely used protein–protein docking
and binding affinity benchmarks. The benchmarks consist of non-redundant, high-quality …
and binding affinity benchmarks. The benchmarks consist of non-redundant, high-quality …
Draft assembly of the Symbiodinium minutum nuclear genome reveals dinoflagellate gene structure
E Shoguchi, C Shinzato, T Kawashima, F Gyoja… - Current biology, 2013 - cell.com
Background Dinoflagellates are known for their capacity to form harmful blooms (eg," red
tides") and as symbiotic, photosynthetic partners for corals. These unicellular eukaryotes …
tides") and as symbiotic, photosynthetic partners for corals. These unicellular eukaryotes …
ProMate: a structure based prediction program to identify the location of protein–protein binding sites
H Neuvirth, R Raz, G Schreiber - Journal of molecular biology, 2004 - Elsevier
Is the whole protein surface available for interaction with other proteins, or are specific sites
pre-assigned according to their biophysical and structural character? And if so, is it possible …
pre-assigned according to their biophysical and structural character? And if so, is it possible …
Protein binding specificity versus promiscuity
G Schreiber, AE Keating - Current opinion in structural biology, 2011 - Elsevier
Interactions between macromolecules in general, and between proteins in particular, are
essential for any life process. Examples include transfer of information, inhibition or …
essential for any life process. Examples include transfer of information, inhibition or …
Predicting free energy changes using structural ensembles
A Benedix, CM Becker, BL de Groot, A Caflisch… - Nature …, 2009 - nature.com
To the Editor: Reliable and fast computation of protein free energy is crucial for protein-
structure analysis, structure-based protein design and protein docking. Rigorous treatments …
structure analysis, structure-based protein design and protein docking. Rigorous treatments …
Bifidobacterium asteroides PRL2011 Genome Analysis Reveals Clues for Colonization of the Insect Gut
Bifidobacteria are known as anaerobic/microaerophilic and fermentative microorganisms,
which commonly inhabit the gastrointestinal tract of various animals and insects. Analysis of …
which commonly inhabit the gastrointestinal tract of various animals and insects. Analysis of …
Tackling the Antibiotic Resistance Caused by Class A β-Lactamases through the Use of β-Lactamase Inhibitory Protein
W Eiamphungporn, N Schaduangrat, AA Malik… - International journal of …, 2018 - mdpi.com
β-Lactams are the most widely used and effective antibiotics for the treatment of infectious
diseases. Unfortunately, bacteria have developed several mechanisms to combat these …
diseases. Unfortunately, bacteria have developed several mechanisms to combat these …