[HTML][HTML] The tubulin code, from molecules to health and disease

ED McKenna, SL Sarbanes… - Annual Review of …, 2023 - annualreviews.org
Microtubules are essential dynamic polymers composed of α/β-tubulin heterodimers. They
support intracellular trafficking, cell division, cellular motility, and other essential cellular …

Unravelling cell migration: defining movement from the cell surface

F Merino-Casallo, MJ Gomez-Benito… - Cell adhesion & …, 2022 - Taylor & Francis
Cell motility is essential for life and development. Unfortunately, cell migration is also linked
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …

Distinct fission signatures predict mitochondrial degradation or biogenesis

T Kleele, T Rey, J Winter, S Zaganelli, D Mahecic… - Nature, 2021 - nature.com
Mitochondrial fission is a highly regulated process that, when disrupted, can alter
metabolism, proliferation and apoptosis,–. Dysregulation has been linked to …

In situ architecture of the ciliary base reveals the stepwise assembly of intraflagellar transport trains

H Van den Hoek, N Klena, MA Jordan, G Alvarez Viar… - Science, 2022 - science.org
The cilium is an antenna-like organelle that performs numerous cellular functions, including
motility, sensing, and signaling. The base of the cilium contains a selective barrier that …

Isotropic super-resolution light-sheet microscopy of dynamic intracellular structures at subsecond timescales

Y Zhao, M Zhang, W Zhang, Y Zhou, L Chen, Q Liu… - Nature …, 2022 - nature.com
Long-term visualization of the dynamic interactions between intracellular structures
throughout the three-dimensional space of whole live cells is essential to better understand …

Field-dependent deep learning enables high-throughput whole-cell 3D super-resolution imaging

S Fu, W Shi, T Luo, Y He, L Zhou, J Yang, Z Yang… - Nature …, 2023 - nature.com
Single-molecule localization microscopy in a typical wide-field setup has been widely used
for investigating subcellular structures with super resolution; however, field-dependent …

[HTML][HTML] iU-ExM: nanoscopy of organelles and tissues with iterative ultrastructure expansion microscopy

V Louvel, R Haase, O Mercey, MH Laporte… - Nature …, 2023 - nature.com
Expansion microscopy (ExM) is a highly effective technique for super-resolution
fluorescence microscopy that enables imaging of biological samples beyond the diffraction …

Enhanced detection of fluorescence fluctuations for high-throughput super-resolution imaging

W Zhao, S Zhao, Z Han, X Ding, G Hu, L Qu… - Nature …, 2023 - nature.com
High-throughput super-resolution (SR) imaging is attractive for rapid and high-precision
profiling in a wide range of biomedical applications. However, current SR methods require …

Event-driven acquisition for content-enriched microscopy

D Mahecic, WL Stepp, C Zhang, J Griffié, M Weigert… - Nature …, 2022 - nature.com
A common goal of fluorescence microscopy is to collect data on specific biological events.
Yet, the event-specific content that can be collected from a sample is limited, especially for …

In situ architecture of Opa1-dependent mitochondrial cristae remodeling

MY Fry, PP Navarro, P Hakim, VY Ananda, X Qin… - The EMBO …, 2024 - embopress.org
Cristae membrane state plays a central role in regulating mitochondrial function and cellular
metabolism. The protein Optic atrophy 1 (Opa1) is an important crista remodeler that exists …