What are white matter hyperintensities made of? Relevance to vascular cognitive impairment

JM Wardlaw, MC Valdés Hernández… - Journal of the …, 2015 - Am Heart Assoc
White matter hyperintensities (WMH) of presumed vascular origin, also referred to as
leukoaraiosis, are a very common finding on brain magnetic resonance imaging (MRI) or …

Impact of diabetes on cognitive function and brain structure

A Moheet, S Mangia… - Annals of the New York …, 2015 - Wiley Online Library
Both type 1 and type 2 diabetes have been associated with reduced performance on
multiple domains of cognitive function and with structural abnormalities in the brain. With an …

Diabetes and cognitive dysfunction

RJ McCrimmon, CM Ryan, BM Frier - The Lancet, 2012 - thelancet.com
Cognitive dysfunction in type 1 and type 2 diabetes share many similarities, but important
differences do exist. A primary distinguishing feature of type 2 diabetes is that people with …

Cognitive function in patients with diabetes mellitus: guidance for daily care

PS Koekkoek, LJ Kappelle, E van den Berg… - The Lancet …, 2015 - thelancet.com
Diabetes mellitus is associated with an increase in the risk of dementia and the proportion of
patients who convert from mild cognitive impairment (MCI) to dementia. In addition to MCI …

Glucose regulation, cognition, and brain MRI in type 2 diabetes: a systematic review

SLC Geijselaers, SJS Sep, CDA Stehouwer… - The Lancet Diabetes & …, 2015 - thelancet.com
Type 2 diabetes is associated with cognitive dysfunction and structural brain changes.
Abnormalities in glucose regulation are involved in several complications related to type 2 …

Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions

GJ Biessels, MWJ Strachan, FLJ Visseren… - The lancet Diabetes & …, 2014 - thelancet.com
Type 2 diabetes is associated with dementia, and also with more slight cognitive
decrements. In this Review we discuss trajectories from normal cognition to dementia in …

Brain changes underlying cognitive dysfunction in diabetes: what can we learn from MRI?

GJ Biessels, YD Reijmer - Diabetes, 2014 - Am Diabetes Assoc
Diabetes is associated with cognitive dysfunction and an increased risk of dementia. This
article addresses findings with brain MRI that may underlie cognitive dysfunction in diabetes …

Prediabetes and diabetes accelerate cognitive decline and predict microvascular lesions: a population-based cohort study

A Marseglia, L Fratiglioni, G Kalpouzos, R Wang… - Alzheimer's & …, 2019 - Elsevier
Introduction The impact of prediabetes and diabetes on cognitive decline and the potential
underlying mechanisms remain unclear. We investigated whether prediabetes and diabetes …

[HTML][HTML] Type 2 diabetes mellitus, brain atrophy and cognitive decline in older people: a longitudinal study

ML Callisaya, R Beare, C Moran, T Phan, W Wang… - Diabetologia, 2019 - Springer
Methods Participants without dementia aged 55–90 years from the Cognition and Diabetes
in Older Tasmanians (CDOT) study underwent brain MRI (ventricular and total brain volume) …

Type 2 diabetes mellitus-associated cognitive dysfunction: advances in potential mechanisms and therapies

A Luo, Z Xie, Y Wang, X Wang, S Li, J Yan… - Neuroscience & …, 2022 - Elsevier
Abstract Type 2 diabetes (T2D) and its target organ injuries cause distressing impacts on
personal health and put an enormous burden on the healthcare system, and increasing …