Retinal degenerative diseases, such as age-related macular degeneration, retinitis
pigmentosa, diabetic retinopathy or glaucoma, represent the main causes of a decreased …

The sodium iodate (NaIO 3) model of increased oxidative stress recapitulates dry AMD
features such as patchy RPE loss, secondary photoreceptors, and underlying …

Oxidative stress and hypoxia in the retinal pigment epithelium (RPE) have long been
considered major risk factors in the pathophysiology of age-related macular degeneration …

Oxidative stress, inflammation and neovascularization are the key pathological events that
are implicated in human age-related macular degeneration (AMD). There are a limited …

Age-related macular degeneration (AMD), one of the leading causes of blindness
worldwide, causes personal suffering and high socioeconomic costs. While there has been …

Oxidative stress in the retinal pigment epithelium (RPE) can cause mitochondrial dysfunction
and is likely a causative factor in the pathogenesis of age-related macular degeneration …

Lipid peroxidation from oxidative stress is considered a major contributor to age-related
macular degeneration (AMD). The retina is abundant with circulating low-density …

Age-related macular degeneration (AMD) is the leading cause of irreversible central vision
loss, typically affecting individuals from mid-life onwards. Its multifactorial aetiology and the …

Background: The aim of this study was to test the feasibility and safety of subretinal
transplantation of human induced pluripotent stem cell (hiPSC)-derived retinal pigment …

Purpose: The lack of suitable animal models for (dry) age-related macular degeneration
(AMD) has hampered therapeutic research into the disease, so far. In this study, pigmented …