5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

The ever-growing number of fluorinated compounds in medicinal and agrochemical
applications has led to a remarkable positive emulation in research. The last few years have …

Biased agonism (or “functional selectivity”) at G-protein-coupled receptors has attracted
rapidly increasing interest as a means to improve discovery of more efficacious and safer …

Positron emission tomography (PET) is an extensively used nuclear functional imaging
technique, especially for central nervous system (CNS) and oncological disorders. Currently …

Atypical antipsychotics fail to substantially improve cognitive impairment associated with
schizophrenia (CIAS) and one strategy to improve it is to stimulate adult neurogenesis in …

Although serotonin 5-HT1A receptors constitute attractive therapeutic targets, there is a lack
of potential clinical candidates that have a high degree of selectivity and full agonist efficacy …

Positron emission tomography (PET) is a molecular imaging modality that enables in vivo
exploration of metabolic processes and especially the pharmacology of neuroreceptors. G …

Background In a previous meta-analysis, the use of serotonin 1A (5-HT 1A) receptor partial
agonists of the azapirone class as an add-on therapy was associated with beneficial effects …

Serotonin receptors (5-HTRs) are implicated in the pathophysiology of a variety of
neuropsychiatric and neurodegenerative disorders and are also targets for drug therapy. In …

Background and Purpose Pattern separation, that is, the formation of distinct representations
from similar inputs, is an important hippocampal process implicated in cognitive domains …