The present perspective article proposes an etiopathological model for multiple sclerosis
pathogenesis and progression associated with the activation of human endogenous …

Importance It remains unclear why only a small proportion of individuals infected with the
Epstein-Barr virus (EBV) develop multiple sclerosis (MS) and what the underlying …

Background Peripheral glial fibrillary acidic protein (GFAP) and neurofilament light chain
(NfL) are sensitive markers of neuroinflammation and neuronal damage. Previous studies …

Herpes viral infection and the multiple sclerosis prodrome: is HHV-6A infection a second hit?
Page 1 Herpes viral infection and the multiple sclerosis prodrome: is HHV-6A infection a …

Intracellular trafficking involves an intricate machinery of motor complexes including the
dynein complex to shuttle cargo for autophagolysosomal degradation. Deficiency in dynein …

Background Multiple sclerosis (MS) is a demyelinating disease affecting millions of people
worldwide. Hereditary susceptibility and environmental factors contribute to disease risk …

Previous exposure to Epstein–Barr virus (EBV) is strongly associated with the development
of multiple sclerosis (MS). By contrast, past cytomegalovirus (CMV) infection may have no …

Background: While John Cunningham virus (JCV) is known to cause neuronal damage in
progressive multifocal leukoencephalopathy (PML) among natalizumab-treated MS patients …

Multiple Sclerosis (MS) is a chronic, neurodegenerative autoimmune disease of the central
nervous system (CNS). The aetiology of the disease remains unknown; however, it is …

Background: Multiple Sclerosis is a chronic demyelinating disease that affects over one
million people in the United States. 1 It occurs through autoimmune mediated destruction of …