Pharmacology and therapeutics of bronchodilators revisited
MG Matera, CP Page, L Calzetta, P Rogliani… - Pharmacological …, 2020 - ASPET
Bronchodilators remain the cornerstone of the treatment of airway disorders such as asthma
and chronic obstructive pulmonary disease (COPD). There is therefore considerable interest …
and chronic obstructive pulmonary disease (COPD). There is therefore considerable interest …
Genetics of chronic respiratory disease
Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD),
asthma and interstitial lung diseases are frequently occurring disorders with a polygenic …
asthma and interstitial lung diseases are frequently occurring disorders with a polygenic …
[HTML][HTML] Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes
The hippocampus is a heterogeneous structure, comprising histologically distinguishable
subfields. These subfields are differentially involved in memory consolidation, spatial …
subfields. These subfields are differentially involved in memory consolidation, spatial …
Genetic advances in chronic obstructive pulmonary disease. Insights from COPDGene
Chronic obstructive pulmonary disease (COPD) is a common and progressive disease that
is influenced by both genetic and environmental factors. For many years, knowledge of the …
is influenced by both genetic and environmental factors. For many years, knowledge of the …
[HTML][HTML] Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes
One life-threatening outcome of cardiovascular disease is myocardial infarction, where
cardiomyocytes are deprived of oxygen. To study inter-individual differences in response to …
cardiomyocytes are deprived of oxygen. To study inter-individual differences in response to …
BAL cell gene expression in severe asthma reveals mechanisms of severe disease and influences of medications
N Weathington, ME O'Brien, J Radder… - American Journal of …, 2019 - atsjournals.org
Rationale: Gene expression of BAL cells, which samples the cellular milieu within the lower
respiratory tract, has not been well studied in severe asthma. Objectives: To identify new …
respiratory tract, has not been well studied in severe asthma. Objectives: To identify new …
Precision Approaches to Chronic Obstructive Pulmonary Disease Management
M Moll, EK Silverman - Annual Review of Medicine, 2024 - annualreviews.org
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality
worldwide. COPD heterogeneity has hampered progress in developing pharmacotherapies …
worldwide. COPD heterogeneity has hampered progress in developing pharmacotherapies …
[HTML][HTML] Multi-omic approach associates blood methylome with bronchodilator drug response in pediatric asthma
Background Albuterol is the drug most widely used as asthma treatment among African
Americans despite having a lower bronchodilator drug response (BDR) than other …
Americans despite having a lower bronchodilator drug response (BDR) than other …
[HTML][HTML] COPD is accompanied by co-ordinated transcriptional perturbation in the quadriceps affecting the mitochondria and extracellular matrix
SAG Willis-Owen, A Thompson, PR Kemp, MI Polkey… - Scientific reports, 2018 - nature.com
Skeletal muscle dysfunction is a frequent extra-pulmonary manifestation of Chronic
Obstructive Pulmonary Disease (COPD) with implications for both quality of life and survival …
Obstructive Pulmonary Disease (COPD) with implications for both quality of life and survival …
Genome‐wide association studies of exacerbations in children using long‐acting beta2‐agonists
EMA Slob, LB Richards, SJH Vijverberg… - Pediatric Allergy and …, 2021 - Wiley Online Library
Background Some children with asthma experience exacerbations despite long‐acting
beta2‐agonist (LABA) treatment. While this variability is partly caused by genetic variation …
beta2‐agonist (LABA) treatment. While this variability is partly caused by genetic variation …