Non-tuberculous mycobacteria (NTM) are paradigmatic colonizers of the total environment,
circulating at the interfaces of the atmosphere, lithosphere, hydrosphere, biosphere, and …

Mycobacterium tuberculosis (MTB) is the main source of tuberculosis (TB), one of the oldest
known diseases in the human population. Despite the drug discovery efforts of past …

Tolerance of Mycobacterium tuberculosis to antibiotics contributes to the long duration of
tuberculosis (TB) treatment and the emergence of drug-resistant strains. M. tuberculosis …

Mycobacterium abscessus is intrinsically resistant to antibiotics effective against other
pathogenic mycobacteria largely due to the drug-induced expression of genes that confer …

SigA (σ A) is an essential protein and the primary sigma factor in Mycobacterium
tuberculosis (Mtb). However, due to the absence of genetic tools, our understanding of the …

Transcriptional activator PafBC is the key regulator of the mycobacterial DNA damage
response and controls around 150 genes, including genes involved in the canonical SOS …

In mycobacteria, σA is the primary sigma factor. This essential protein binds to RNA
polymerase (RNAP) and mediates transcription initiation of housekeeping genes. Our …

Tuberculosis (TB) remains the leading cause of death due to a single pathogen, accounting
for 1.5 million deaths annually on the global level. Mycobacterium tuberculosis, the …

Mycolactone is a cytotoxic lipid metabolite produced by Mycobacterium ulcerans, the
environmental pathogen responsible for Buruli ulcer, a neglected tropical disease …

Under starvation conditions, bacteria tend to slow down their translation rate by reducing
rRNA synthesis, but the way they accomplish that may vary in different bacteria. In …